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At 18, Jeanne Schaller left home
to spread her wings.
At 81, she's doing it again.
Springhouse
Assisted Living
phosphates and binding to other
intracellular proteins—both key
steps in insulin signaling.
"Now that we know that the
plackstrin homology region is im-
portant," Professor Zick says, "we
can set a long-term goal of en-
hancing its binding capacity as
a possible method of helping di-
abetes patients."
This research reflects a new
approach to diabetes treatment
adopted by a number of major re-
search laboratories around the
world. Rather than attacking the
problem from the "outside" by in-
jecting insulin, attempts are now
being made to solve the problem
from the "inside" by clarifying the
steps involved in the transfer of
insulin signals, and making this
process more efficient.
"Although this approach holds
life. For more information, call us at (810) 358-0088.
Springhouse. Where older adults get a helping hand.
She's an independent woman. But if she's going
to live her own life, she'll need a little assistance now
and then.
If you or someone you love is looking for a warm,
caring environment where independence is respect-
ed and a helping hand is always nearby, we can help.
Introducing Springhouse Assisted Living, now
open in Southfie:d.
We have a highly qualified staff to provide assis-
tance when it's needed, as well as features like an ice
cream parlor, formal dining room, country kitchen
and outdoor terrace to share with visiting family and
friends.
Regular wellness assessments let us work closely
with each resident to help them get the most out of
A Member of the Manor Care Family of Companies
PROTEIN REGION page 57
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A SSISTED LIVING
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(810) 358-0088
201 I I Tc1cgiciph Rock!
SociatlicIcI, MI 480.3-1
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GREAT GIFT ID EAS
* Leather Jackets & Leather Sweaters * Vests * Formal Wear
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HOLIDAY HOURS NOVEMBER 26 thru DECEMBER 17
Mon.- Sat. 9:30-6, Thurs. 9:30-7, SUN. 12-4
19011 W. 10 Mile Rd.
(between Southfield & Evergreen)
Southfield, MI 48075
Snow Shoveling Could
Pose Heart Attack Risk
eople who have one or
more of the major risk fac-
tors for heart disease
should think twice before
shoveling heavy snow, accord-
ing to researchers at William
Beaumont Hospital in Royal
Oak.
A Beaumont-based study
published in the Journal of the
American Medical Association
A cichISS
810-352-1080
out much promise as a solution
for the future, many obstacles
still must be overcome before we
can devise an effective therapy,"
Professor Zick says. "First, the
various elements involved in in-
sulin signal transfer must be cor-
rectly identified. Second,
whatever drugs are given must
be specific, so that we don't cure
one disease while exacerbating
another. Third, we must find an
effective way to deliver these
drugs through the plasma mem-
brane and into the cell. Finally,"
Professor Zick says, "it is gener-
ally easier to repress protein ac-
tion than to stimulate it, as we
must do in the case of diabetes.
We are still in stage one of this
endeavor—defining the players
in the game." ❑
(JAMA) shows just two minutes
of shoveling heavy, wet snow
can raise your heart rate and
blood pressure to levels equal to
or exceeding the maximum aer-
obic workout, and may lead to
heart attack in inactive people
at risk for heart disease.
The study details the exces-
sive cardiac demands of the
manual snow shoveling and a
link with the high number of
heart-related deaths and com-
plications often reported after a
major snowstorm, says lead re-
searcher Dr. Barry Franklin, di-
rector of Beaumont's
Department of Cardiac Reha-
bilitation.
"Based on our study, we be-
lieve those with a family or per-
sonal history of heart problems,
or who have one or more of the
major risk factors for heart dis-
ease, should think twice about
shoveling snow, or not do it at
all," Dr. Franklin says.
Major risk factors for heart
disease include sedentary
lifestyle, smoking, high blood
pressure and elevated blood cho-
lesterol.
The Beaumont researchers
monitored heart rate, blood pres-
sure and oxygen consumption
during snow removal in 10 ap-
parently healthy, sedentary men
(average age: 32 years old.) Each
participant cleared two 4-inch
tracts of heavy, wet snow using
a shovel, then an electric snow
thrower. The results were com-
pared with the same measure-
ments taken during maximum
fitness testing using a treadmill
and ai in-cranling device.
The researchers found that
peak heart rates during shovel-S
ing and fitness testing were com-
parable, at rates exceeding 170
beats-per-minute. After only two
minutes of shoveling, heart rates
exceeded the upper limit rec-
ommended for aerobic exercise
training. Study participants who
were the least physically fit had
the highest heart rates while
shoveling.
The study says five factors
may contribute to excessive de-
mands of manual snow shovel-
ing on the heart: upper body
exercise, upright posture, and
isometric exertion. Holding one's
breath and inhaling cold air may
further constrict the heart's
blood vessels. In a person with
hidden or known heart disease,
these factors may lead to inad-
equate oxygen supply to the
heart muscle, chest pain or ir-
regular heart rhythms.
Heart attack deaths are fre-
quently reported in the lay press
in the wake of heavy snow-
storms. For example, at least 22
people in the Detroit metropol-
itan area suffered heart attacks
following a January 1992 snow-
storm.
Dr. Franklin offers safety tips
for people who are considering
snow shoveling:
• Elderly persons, those with
high blood pressure, or those
with a family history or at high
risk for heart disease simply
should not shovel snow.
• For those who shovel, pace