We Pay for Moving Expenses • Call For Details At 18, Jeanne Schaller left home to spread her wings. At 81, she's doing it again. Springhouse Assisted Living phosphates and binding to other intracellular proteins—both key steps in insulin signaling. "Now that we know that the plackstrin homology region is im- portant," Professor Zick says, "we can set a long-term goal of en- hancing its binding capacity as a possible method of helping di- abetes patients." This research reflects a new approach to diabetes treatment adopted by a number of major re- search laboratories around the world. Rather than attacking the problem from the "outside" by in- jecting insulin, attempts are now being made to solve the problem from the "inside" by clarifying the steps involved in the transfer of insulin signals, and making this process more efficient. "Although this approach holds life. For more information, call us at (810) 358-0088. Springhouse. Where older adults get a helping hand. She's an independent woman. But if she's going to live her own life, she'll need a little assistance now and then. If you or someone you love is looking for a warm, caring environment where independence is respect- ed and a helping hand is always nearby, we can help. Introducing Springhouse Assisted Living, now open in Southfie:d. We have a highly qualified staff to provide assis- tance when it's needed, as well as features like an ice cream parlor, formal dining room, country kitchen and outdoor terrace to share with visiting family and friends. Regular wellness assessments let us work closely with each resident to help them get the most out of A Member of the Manor Care Family of Companies PROTEIN REGION page 57 r 1111)Ch LI IC 011 Sp1ing/1(41SC. PICLISC SCI1c1 ITIC p Slate City Z ip Phom r A SSISTED LIVING ASSISTED (810) 358-0088 201 I I Tc1cgiciph Rock! SociatlicIcI, MI 480.3-1 JN GREAT GIFT ID EAS * Leather Jackets & Leather Sweaters * Vests * Formal Wear * Greg Peters Wool Gab Slacks * French Cuff Dress Shirts (/) UJ Lu C.) CC LU D LU 58 HOLIDAY HOURS NOVEMBER 26 thru DECEMBER 17 Mon.- Sat. 9:30-6, Thurs. 9:30-7, SUN. 12-4 19011 W. 10 Mile Rd. (between Southfield & Evergreen) Southfield, MI 48075 Snow Shoveling Could Pose Heart Attack Risk eople who have one or more of the major risk fac- tors for heart disease should think twice before shoveling heavy snow, accord- ing to researchers at William Beaumont Hospital in Royal Oak. A Beaumont-based study published in the Journal of the American Medical Association A cichISS 810-352-1080 out much promise as a solution for the future, many obstacles still must be overcome before we can devise an effective therapy," Professor Zick says. "First, the various elements involved in in- sulin signal transfer must be cor- rectly identified. Second, whatever drugs are given must be specific, so that we don't cure one disease while exacerbating another. Third, we must find an effective way to deliver these drugs through the plasma mem- brane and into the cell. Finally," Professor Zick says, "it is gener- ally easier to repress protein ac- tion than to stimulate it, as we must do in the case of diabetes. We are still in stage one of this endeavor—defining the players in the game." ❑ (JAMA) shows just two minutes of shoveling heavy, wet snow can raise your heart rate and blood pressure to levels equal to or exceeding the maximum aer- obic workout, and may lead to heart attack in inactive people at risk for heart disease. The study details the exces- sive cardiac demands of the manual snow shoveling and a link with the high number of heart-related deaths and com- plications often reported after a major snowstorm, says lead re- searcher Dr. Barry Franklin, di- rector of Beaumont's Department of Cardiac Reha- bilitation. "Based on our study, we be- lieve those with a family or per- sonal history of heart problems, or who have one or more of the major risk factors for heart dis- ease, should think twice about shoveling snow, or not do it at all," Dr. Franklin says. Major risk factors for heart disease include sedentary lifestyle, smoking, high blood pressure and elevated blood cho- lesterol. The Beaumont researchers monitored heart rate, blood pres- sure and oxygen consumption during snow removal in 10 ap- parently healthy, sedentary men (average age: 32 years old.) Each participant cleared two 4-inch tracts of heavy, wet snow using a shovel, then an electric snow thrower. The results were com- pared with the same measure- ments taken during maximum fitness testing using a treadmill and ai in-cranling device. The researchers found that peak heart rates during shovel-S ing and fitness testing were com- parable, at rates exceeding 170 beats-per-minute. After only two minutes of shoveling, heart rates exceeded the upper limit rec- ommended for aerobic exercise training. Study participants who were the least physically fit had the highest heart rates while shoveling. The study says five factors may contribute to excessive de- mands of manual snow shovel- ing on the heart: upper body exercise, upright posture, and isometric exertion. Holding one's breath and inhaling cold air may further constrict the heart's blood vessels. In a person with hidden or known heart disease, these factors may lead to inad- equate oxygen supply to the heart muscle, chest pain or ir- regular heart rhythms. Heart attack deaths are fre- quently reported in the lay press in the wake of heavy snow- storms. For example, at least 22 people in the Detroit metropol- itan area suffered heart attacks following a January 1992 snow- storm. Dr. Franklin offers safety tips for people who are considering snow shoveling: • Elderly persons, those with high blood pressure, or those with a family history or at high risk for heart disease simply should not shovel snow. • For those who shovel, pace