2A - Wednesday, January15, 2014
The Michigan Daily - michigandaily.com
iEht filgan DAMl
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CAMF M RDI
Furman U. recieves $1M gift
Furman University in Green-
ville, South Carolina, received
$1 million through the Duke
Endowment, the Greenville
News reported. The grant went
to support the work of the Riley
Institute, the public policy orga-
nization devoted to improving
the social and economic condi-
tions of the state.
The Duke Endowment, a pri-
vate foundation established by
philanthropist James B. Duke to
support the people of North and
South Carolina, rewarded the
Riley Institute for its focus on
"education, diversity and critical
issues impacting the state,"
The fund also aimsto strength-
en the pubhlic policy programs
that benefit Furman students,
faculty and residents across the
state in the areas of public edu-
cation, economic development,
leadership, diversity and other
issues.
Police investigate bomb hoax
at Texas State University
The Texas State University-
San Marcos campus received a
bomb threatcearly Tuesday morn-
ing that was later found to be a
hoax, KXXAN News reported.
The Texas State University
Police investigated the campus
throughout the morning, initially
closing downa residence hall and
surrounding areas, but found no
sign of explosives.
Police arrested suspect Clay-
ton Garland Warren, a 24-year-
old man who is accused of issuing
the bomb threat. He is currently
in custody at Hays County Jail
and faces three criminal charges,
according to Texas State Univer-
sity spokesman Jayme Blaschke.
Warren's vehicle contained two
suspicious devices, but were later
declared not explosive. Blaschke
said the fakebombs were designed
as real explosives and criminal
intent remains unknown.
Students living in College Inn,
a large co-ed dorm on campus
with 300 residents, were forced
to spend more than four hours
at the student recreation center
while police searched the area.
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LSA freshman Lester Lee plays table teSis during
Winterfest Tuesday afternoon.
CRIME NOTES
CAMPUS EVENTS & NOTES
Slipping and Golf cart
sliding getaway
WHERE: Couzens Hall
WHEN: Monday at about
10:10 a.m.
WHAT: A Student was
taken to the University
Emergency Department
after falling, University
police reported.
WHERE: Stadium Gate 1
WHEN: Monday at 12:15
p.m.
WHAT: A rented golf cart
was stolen from the loading
dock area at about 3:00 p.m.,
University Police reported.
There are currently no
suspects.
Eco-friendly Where's the
thievery beef?
Saxophone Lecture on
performance 'being nuclear'
WHAT: Saxophonist, Uni- WHAT: University profes-
versity alum and member of sors discuss what it means
the band Bon Iver will give to be "nuclear" - whether it
an emotionally gripping be a state or an object.
preformance. WHO: Gabrielle Hecht and
WHO: Colin Stetson Elizabeth Roberts
WHEN: 7:30 p.m. WHEN: 5:30 - 7:00 p.m.
WHERE: Walgreen Drama WHERE: Harlan Hatcher
Center, Arthur Miller Graduate Library, Room 100
Theatre
CORRECTIONS
The Deadly A previous version of the
article "University Provost
Gentlemen defines Shared Services task
plans"printed Tuesday,
performance Jan.15 misstated the name
of the overall service reform
WHAT: The group will play plan. It is the Administra-
a classical set with a modern tive Services Transforma-
twist from their new album, tion, not the Administration
"Roll Me, Tumble Me." Services Transition.
WHO: The Deadly
Gentlemen 0 Please report any error
WHEN: 8:00 p.m. in the Daily to correc-
WHERE: The Ark, 316S. tions@michigandaily.com.
In true Walter White
fashion, blue meth is
being sold in New Mexi-
co and the greater Four Cor-
ners region, the Huffington
Post reported. The drugs
have been making people
sick, reportedly because of
the chemicals to make itblue.
Is faith fading on
campus? Data reveals
fewer students are
identifying with religion at
the University. The Statement
delves into reasons behind
the decline.
g FOR MORE, SEE THE STATEMENT,
A Chinese commer-
cial for Rio Burgundy
Grape Mint caused
controversy when the pro-
tagonist of the ad is so over-
come by the powerful flavor
of the mint he fails to notice
his stuffed purple llama lick-
ing his chest, ABC reported.
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WHERE: 900 Block, S.
University Ave.
WHEN: Thursday at 12:50
a.m.
WHAT: Abike was stolen
from a rack in front of Sha-
piro Undergraduate Library
the previous night, Univer-
sity Police reported. There
are currently no suspects.
WHERE: University Hos-
pital
WHEN: Tuesday at about
2:20 a.m.
WHAT: A subject stole food
from the cafeteria without
paying and left the building,
University Police reported.
Subject was 34 years old
and arrested soon after.
MORE ONLINE Love Crime Notes?
Get morefonline at michigandaily.com/blogs/The Wire
'U' protein research could
lead to better drug treatment
Professors study
how water affects
molecular functions
By TOM MCBRIEN
Daily StaffReporter
Much like students at a club
on a Saturday night, proteins can
act differently when crowded
together than when they are
more spread out.
A team of University research-
ers is at the forefront of studying
this phenomenon as they focus on
how water acts between proteins
surrounded by bulky molecules,
known as crowded proteins. The
research may enable scientists to
better understand how proteins
work, which can lead to improved
drug treatments in the future.
The researchers' paper,
"Crowding Induced Collective
Hydration of Biological Macro-
molecules over Extended Dis-
tances," was recently published
in the Journal of the American
Chemical Society and is acces-
sible online.
Proteins called enzymes carry
out many crucial chemical reac-
tions in the body. They are often
studied in terms of the molecules
they bind to carry out these life-
sustaining reactions. However,
an aspect of protein chemistry
that has been overlooked is that
they are almost always acting in
crowded, watery environments.
Assistant Chemistry Prof.
Kevin Kubarych said crowded
environments can alter the way
in which we view protein activity.
"When you stuff people
together, like kids at a club - as
the walls of the club start to get
closer and closer together, the
music might be the same and the
dancing might be similar, but the
way that the actual motion of
people works through the club
is going to change. If you want to
go from here to there, you have
to mess with 25 people on your
way,"Kubarych said.
In the researchers' model,
crowding of proteins causes
the water surrounding them
to slow down. In keeping with
Kubarych's example, they have
less room to move in the club.
As a result, the proteins, which
normally fluctuate in shape, also
begin to slow down.
"If the solute is just protein,
that means that proteins are indi-
rectly sharing information with
each other through this attribute
of water," Kubarych said.
The information could have
important pharmaceutical and
medical implications. Each pro-
tein has very specific molecules
called substrates to which it
binds and on which it performs
certain actions. For example,
the protein salivary amylase,
present in human saliva, starts
breaking food apart as it's eaten.
Dr. Margaret R. Gyetko, senior associate dean for Faculty and Faculty Development at University Medical School, speaks
about promotions and tenure at the Towsley Center Tuesday.
Medical School hosts town
halls to talk pro-motion
I
,-S
Many important drugs work by
closely mimicking substrates
that proteins would normally
bind to, keeping them from bind-
ing to their normal substrates
and thus causing some change in
the body.
Exactly how well proteins bind
to their substrates and how quick-
8 ly this happens depends on a host
of factors, one of which may have
to do with the state of the water
surroundingthe protein.
Kubarych said crowding could
affect water molecules, which then
affects unbound proteins' fluctua-
tions, changing the way in which
theybind to their substrates.
Knowing more about how pro-
teins respond to crowding could
illuminate more about the speed
at which they bind to certain
drugs, which can be the differ-
ence between life and death in
some cases.
"Waiting for one or two days
7 for your drug to take effect -
that's only a factor of two in
chemistry but can make a huge
difference for a sick person,"
Kubarych said.
Meetings address
issues from dean's
annual speech
By CAROLINE BARON
For the Daily
Even doctors need a reminder
that in order to succeed, you have
to ask for what you want.
Margaret Gyetko, the senior
associate dean for faculty and
faculty development at the Uni-
versity Medical School, held a
seminar Tuesday to address the
ways that the Medical School's
faculty members can best earn
promotions and tenure.
The meeting was part of a
series hostedby the school's dean,
James Woolliscroft, as a way to
promote interaction between the
Medical School community and
its leadership. The series of town
halls supplement issues raised in
Woolliscroft's State of the School
presentation, which was held in
September.
Thiseventwas Gyetko'sseventh
seminar on the topic. The idea for
the series first emerged after she
received large numbers of poorly
prepared promotion packages
from the school's faculty.
"I had been getting a lot of
applications where it was very
clear to me that (the applicants)
were smart and talented, but they
didn't know how to plan ahead in
a waybest conducive to achieving
promotions," Gyetko said. "You
know, we have an amazing and
brilliant faculty, but the only way
to win the game is to know the
rules, and know if you're ahead or
behind."
The seminar focused on what
aspects are most valued and scru-
tinized by the school's leadership
when making decisions about
promotions of faculty members.
Gyetko's talk focused on differ-
ent ways that faculty could pre-
pare their promotion packages to
make themselves mostappealing,
as well as the types of goals they
try to achieve that would make
them ideal candidates for a pro-
motion in the future.
Gyetko added that the timeline
to obtain a promotion is long and
cannot be rushed in the five years
before a faculty member requests
career advancement. She also
said it's important for faculty
to understand that moving up
is natural and that they should
strive for it.
During the seminar, Gyetko
said she recommends cultivating
relationships with people in the
same field, following through on
promises and ensuring prepared-
ness for the added responsibili-
ties that accompany a promotion.
She also drew attention to a pro-
gram available at the Medical
School to help facultyassess their
readiness before beginning to
prepare promotion packages.
The entire lecture is available
for viewing on the UMHS website.
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