Thursday, October 28, 1976 TEMCIA AL
THE MICHIGAN DAILY
Page Three
Scientists
report
DNA
breakthrough
SAN FRANCISCO (A') - Sci- As a result of recombinant In
entists experimenting with DNA research, he said, cellsn
genes have "ordered" a tiny could be ordered to produce
cell to produce an enzyme, a drugs like insulin, essential to
discovery they say may lead to the survival of about a third of1
new, less expensive sources of the nation's 10 million diabetics. If
insulin and other drugs. Boyer, who directed the re-!
In an interview before pub- search at the University of Cali-b
lication today of the findings in fornia - San Francisco, said suchI
the journal Nature, Dr. Her- production might be only fivea
bert Boyer said scientists may years away.I
soon be able to reconstruct The genetic engineering is'
genes that will turn cells into based on the research reported
"factories" for the production in 1973 and 1974 and for which
of biological substances. the University of California and
"WE'VE GONE out of theStaUforsierCity rae ndo
area of basic science," Boyer. Stanford University have to-
said, "into the area of practical gether applied for a patent oni
application." the commercial use of the tech-
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B O Y E R ' S W O R K in
reconstructing parts of parts
for DNA, the basic chemical
unit of heredity, "parallel" the
break - through announced last
August by Har Gobind K'horana
and others at the Massachusetts
Institute of Technology, the
University of California said.
The Khorana group succeed-
ed in linking complex chains of
DNA to duplicate the actual !
gene of a simple bacterium, E.
coli, which lives in the human
intestine. When this manmade
gene was then inserted into the
cell, it fnctioned like its real-
life model.
Boyer explained his group
has synthesized a section of
- - - - - + .__
DNA that orders the genes of
E. coli to produce an enzyme
used for digesting milk. Nor-
mally the enzyme is produced
only when the cell needs it.
"NO R M A L L Y THERE'S
Scientists think repressor
molecules are part of the rea-
son one gene in a human fetus
will direct cells to form into a
hand and another, perfectly
identical gene, will order the
development of a nose.
a protein molecule that sits on
top of this genetic segment and B 0 Y E R said the biggest
keeps it from working," Boyer stumbling block in making ge-
explained. Such molecules, call- netics work for man in produc-
those used in the UCSF and MIT
research.
"Putting it into the cell is a
snap," he said. "We have the
technology for that. DNA syn-
thesis is still very expensive
and time consuming."
The first known patent for
rayon was taken out in 1855 by
George Andemars, but rayon
was perfected by Sir Joseph
Swan in 1883.
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ed "repressors," are important
clues to understanding what
turns a gene on and off.
When the manmade DNA was
inserted into the cell, Boyer
said, it grabbed the repressor{
molecule away from the cell's
own DNA, which then began to
order the gene to produce the
enzyme.
ing insulin and other drugs is
the laborious synthesizing of
DNA segment sand genes that
are more complicated than
U
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STE
DEMOCRAT fir
PROSECUTING ATTORNEY
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As attorney for the people, and their chief law enforce-
ment official, the prosecuting attorney has a more direct
and significant impact on the daily lives of county resi-
dents, on campus and off, than any other official to be
elected November 2nd.4
The prosecuting attorney can concentrate limited criminal
iustice resources in such critical areas as rape, rubbery,
consumer fraud and environmental abuse: or, like the
incumbent, he can waste these resources pursuing victim-
less offenses. The prosecuting attorney can see that tenants
are protected from unsafe housina, that nursing home
patients are protected from physical and fiscal abuse, and
that the whole community is protected from collusive price-
fixing that artificially inflates prices for groceries and
other merchandise; or, like the incumbent, he can ignore
these problems. The prosecutina attorney can bring the
concept of equal justice closer to reality; or, like the in-
cumbent, he can continue with a system of double stand-
ards, one for the privileged few and another for the rest
of us. An energetic, committed prosecuting attorney can
have a positive impact on our lives.
George Steeh, a native of Washtenaw County, earned his
bachelor's and law degrees from the University of Michigan.
He had experience in the best prosecutor's office in the
state, where he was a Senior Assistant Prosecuting Attor-
ney. He has been chief of a nationally acclaimed Economic
Crime Unit. Steeh has extensive experience with both civil
and criminal trials and appeals. He has proven ability in
effectively managing a staff and case load more than
twice as large as the Washtenaw County prosecutor's
Steeh is a nationally recognized leader in developing irno-
votive,- effective approaches to confront the crime problem.
In the prosecuting attorney's office, we need dynamic
leadership, effective management and fair treatment of
all citizens. George Steeh has the energy, concern and
ability to do the job for us.
Paid for by Steeh for Prosecuting Attorney
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LEADING BASS OF THE METROPOLITAN OPERA
Basso Diaz' rise to international fame has been spectacular since the opening of the new
Metropolitan Opera at Lincoln Center when he portrayed the male lead in Samuel
Barber's "Antony and Cleopatra." His successes on the world's major operatic stages
are combined with guest artist appearances with the great orchestras of the United
States and Canada, Europe and South America, and he returns regularly to his home-
land, Puerto Rico, to sing at the Casals Festivals.
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