8
Thursday, June 14, 2018
The Michigan Daily — michigandaily.com
NEWS
1014 VAUGHN AVAIL Fall 2018
#1 is being rented by the room for
$700/m including utilities
If you have a group of 5, rent the whole
unit for $3100 plus Electric to DTE
#2 is a 6 Bdrm for $3720 plus Electric
to DTE • 734‑996‑1991
1015 PACKARD
4 Bdrm Apt Avail Fall 2018
2 parking space, onsite laundry, 1st
floor
$2830 + Electric to DTE •
734‑996‑1991
\
422 HAMILTON
2 & 3 Bdrm Avail Fall 2018
#2 ‑ 3 bdrm ‑ 2nd floor ‑ $2350
#3 ‑ 2 bdrm ‑ 3rd fl ‑ $1550
Tenants pay gas and electric to DTE
Showings M‑F 10‑3 • 734‑996‑1991
CENTRAL CAMPUS, FUR-
NISHED rooms for students, shared
kitch., ldry., bath., internet,
rent from $700 and up. Call
734‑276‑0886.
HOUSES AVAILABLE FALL 2018
1016 Packard ‑ 4/6 Bdrm ‑
$3080‑$4020
401 Pauline ‑ 4 Bdrm ‑ $2900
827 Brookwood ‑ 4 Bdrm ‑ $2900
Showings M‑F 10‑3 • 734‑996‑1991
FOR RENT
Classifieds
Call: #734-418-4115
Email: dailydisplay@gmail.com
1014 VAUGHN AVAIL Fall 2018
#1 is being rented by the room for
$700/m including utilities
Classifieds
Call: #734-418-4115
Email: dailydisplay@gmail.com
ACROSS
1 Common
borrowing result
5 Add one’s two
cents, with “in”
10 “So that’s what
that means!”
13 Novelist
John le ___
15 Resort near Vail
16 “Hansel and
Gretel” figure
17 Pigmented eye
parts
18 Devour, with
“down”
19 Outback bird
20 Longtime
network symbol
22 Historical display
24 Lucy’s co-star
25 Sandal features
26 Hardly helpless
28 Solemn oath
30 Subj. that may
include a lab
31 Potting need
32 Skater who lit the
Olympic cauldron
in Nagano
33 Responses from
a sycophant
36 Refine
37 House of __
39 Student stressor
41 Cut even shorter,
as a green
43 Loophole
44 Times in
classifieds
45 “Bambi” doe
46 A
47 Small deer
48 Not a good fit
51 Heavy hammer
53 They’re run in
taverns
54 Standoffish
57 Cracker lacking
pop
58 Producer Scott
with Emmy,
Grammy, Oscar
and Tony wins
60 Tsar’s decree
61 Mimic
62 Poker declaration
63 Private student
64 Strong desire
65 Spot __
66 Scorch
DOWN
1 Bra spec
2 Holiday lights
may be under
one
3 Depression Era
sight
4 Cobalt in the
human body, e.g.
5 Wine container
6 TV buying
channel
7 Apple Store buys
8 Promotion criteria
9 Carry out, as
laws
10 Lots
11 Actor Jon and
others
12 Rio contents
14 Those, in Tijuana
21 Certain 19th-
century history
specialist
23 Cause
commotion ... or
what the circled
letters do?
25 Smallish, as an
apartment
26 Tapped-off
remnant
27 Uncouth sort
29 Oklahoma people
34 Use a micro-
dermabrasion
agent, say
35 Make fully
content
38 Hound for
payment
40 Submissions to
eds.
42 Quebec neighbor
48 Brownish gray
49 Elizabeth of
beauty products
50 FAA overseer
52 Été month
53 Gift-giving
occasion, for
short
54 Shave-haircut
link
55 No longer in port
56 Not a good look
59 Land in la mer
By Joe Kidd
©2018 Tribune Content Agency, LLC
06/14/18
06/14/18
ANSWER TO PREVIOUS PUZZLE:
RELEASE DATE– Thursday, June 14, 2018
Los Angeles Times Daily Crossword Puzzle
Edited by Rich Norris and Joyce Nichols Lewis
CHECK OUT OUR COOL
www.michigandaily.com
WEBSITE.
NOW.
New cancer study
U-M researcher’s
discovery leads to
potential improvement
of cancer therapy
By ROB DALKA
Daily Staff Reporter
Researchers at the Univer-
sity of Michigan Rogel Cancer
Center have determined cancer
cells seize control of the meta-
bolic pathways within specific
immune cells to suppress the
immune system and accelerate
tumor growth.
Immune suppressor cells that
exist in cancerous tumors block
the body’s natural defense sys-
tem, and a high volume of these
immune suppressor cells can ren-
der the immune system ineffec-
tive at fighting tumor growth.
Previously, researchers had lit-
tle understanding of what caused
the development of immune sup-
pressor cells but did recognize
the necessity of a healthy immune
system in the battle against can-
cer. Immunotherapy, which har-
nesses a patient’s own immune
system to fight cancer, has been
very successful for survivors of
certain cancers.
“Immunotherapy
includes
treatments that work in differ-
ent ways,” the American Can-
cer Society states on its website.
“Some boost the body’s immune
system in a very general way.
Others help train the immune
system to attack cancer cells spe-
cifically.”
The
limited
understand-
ing of the immune-suppressing
cells makes it difficult to treat
certain types of cancers using
immunotherapy. Cancers, such
as triple-negative breast cancer
– the cancer cell line used in this
research because of its prominent
immune suppressor cells – are
especially difficult to treat. Tri-
ple-negative breast cancer lacks
three common receptors that
stimulate tumor growth, making
it harder to treat.
“Since the tumor cells lack the
necessary receptors, common
treatments like hormone therapy
and drugs that target estrogen,
progesterone, and HER-2 are
ineffective,” the National Breast
Cancer Foundation states on
its website. Chemotherapy is
often a triple-negative breast
cancer patient’s only option.
Weiping Zou, a renowned
professor of surgery and pri-
mary researcher in the study,
explained the issue with cur-
rent
immunotherapy
treat-
ment.
“Immunotherapy works very
well for some patients, but not
everyone is responsive to the
treatment,” Zou said. “Through
this study we hope to improve the
current treatment to make it bet-
ter for more people.”
During
the
project,
the
researchers studied the tumors’
growth in mice, approved by
the committee on Use and Care
of Animals at the University of
Michigan. They were able to mea-
sure the growth of the tumors
and find the factors that caused
the processes within them. The
researchers also studied culti-
vated cells separately. Extensive
measurements were taken during
the experiment on tumor growth
and cell production which were
then analyzed using various data
analytical techniques.
Dr. Inka Kryczek, Research
Assistant Professor of Surgery,
summarized the various parts of
the process they studied.
“We looked at the metabolic
pathways, the immunosuppres-
sive cells themselves, and the
biology of the tumor. It proved to
be a very comprehensive study.”
said Kryczek.
The new research sheds some
light on what could be causing
the development of the immune
suppressor cells. A link found
between the metabolic produc-
tion of glycolysis and the number
of the immune suppressor cells
present in the tumor showed a
direct correlation between an
increase in glycolysis and an
increase in immune suppressor
cells.
Zou believes the discovery
can lead to new treatments for
patients that exhibit high num-
bers of the immune suppressor
cells.
“We hope we can manipulate
the metabolic pathways to devel-
op an immunotherapy approach
to help these patients,” Zou said.
Zou
also
anticipates
the
research
will
inspire
other
researchers to develop better
techniques for treatment.