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HOUSES AVAILABLE FALL 2018 1016 Packard ‑ 4/6 Bdrm ‑ $3080‑$4020 401 Pauline ‑ 4 Bdrm ‑ $2900 827 Brookwood ‑ 4 Bdrm ‑ $2900 Showings M‑F 10‑3 • 734‑996‑1991 FOR RENT Classifieds Call: #734-418-4115 Email: dailydisplay@gmail.com 1014 VAUGHN AVAIL Fall 2018 #1 is being rented by the room for $700/m including utilities Classifieds Call: #734-418-4115 Email: dailydisplay@gmail.com ACROSS 1 Common borrowing result 5 Add one’s two cents, with “in” 10 “So that’s what that means!” 13 Novelist John le ___ 15 Resort near Vail 16 “Hansel and Gretel” figure 17 Pigmented eye parts 18 Devour, with “down” 19 Outback bird 20 Longtime network symbol 22 Historical display 24 Lucy’s co-star 25 Sandal features 26 Hardly helpless 28 Solemn oath 30 Subj. that may include a lab 31 Potting need 32 Skater who lit the Olympic cauldron in Nagano 33 Responses from a sycophant 36 Refine 37 House of __ 39 Student stressor 41 Cut even shorter, as a green 43 Loophole 44 Times in classifieds 45 “Bambi” doe 46 A 47 Small deer 48 Not a good fit 51 Heavy hammer 53 They’re run in taverns 54 Standoffish 57 Cracker lacking pop 58 Producer Scott with Emmy, Grammy, Oscar and Tony wins 60 Tsar’s decree 61 Mimic 62 Poker declaration 63 Private student 64 Strong desire 65 Spot __ 66 Scorch DOWN 1 Bra spec 2 Holiday lights may be under one 3 Depression Era sight 4 Cobalt in the human body, e.g. 5 Wine container 6 TV buying channel 7 Apple Store buys 8 Promotion criteria 9 Carry out, as laws 10 Lots 11 Actor Jon and others 12 Rio contents 14 Those, in Tijuana 21 Certain 19th- century history specialist 23 Cause commotion ... or what the circled letters do? 25 Smallish, as an apartment 26 Tapped-off remnant 27 Uncouth sort 29 Oklahoma people 34 Use a micro- dermabrasion agent, say 35 Make fully content 38 Hound for payment 40 Submissions to eds. 42 Quebec neighbor 48 Brownish gray 49 Elizabeth of beauty products 50 FAA overseer 52 Été month 53 Gift-giving occasion, for short 54 Shave-haircut link 55 No longer in port 56 Not a good look 59 Land in la mer By Joe Kidd ©2018 Tribune Content Agency, LLC 06/14/18 06/14/18 ANSWER TO PREVIOUS PUZZLE: RELEASE DATE– Thursday, June 14, 2018 Los Angeles Times Daily Crossword Puzzle Edited by Rich Norris and Joyce Nichols Lewis CHECK OUT OUR COOL www.michigandaily.com WEBSITE. NOW. New cancer study U-M researcher’s discovery leads to potential improvement of cancer therapy By ROB DALKA Daily Staff Reporter Researchers at the Univer- sity of Michigan Rogel Cancer Center have determined cancer cells seize control of the meta- bolic pathways within specific immune cells to suppress the immune system and accelerate tumor growth. Immune suppressor cells that exist in cancerous tumors block the body’s natural defense sys- tem, and a high volume of these immune suppressor cells can ren- der the immune system ineffec- tive at fighting tumor growth. Previously, researchers had lit- tle understanding of what caused the development of immune sup- pressor cells but did recognize the necessity of a healthy immune system in the battle against can- cer. Immunotherapy, which har- nesses a patient’s own immune system to fight cancer, has been very successful for survivors of certain cancers. “Immunotherapy includes treatments that work in differ- ent ways,” the American Can- cer Society states on its website. “Some boost the body’s immune system in a very general way. Others help train the immune system to attack cancer cells spe- cifically.” The limited understand- ing of the immune-suppressing cells makes it difficult to treat certain types of cancers using immunotherapy. Cancers, such as triple-negative breast cancer – the cancer cell line used in this research because of its prominent immune suppressor cells – are especially difficult to treat. Tri- ple-negative breast cancer lacks three common receptors that stimulate tumor growth, making it harder to treat. “Since the tumor cells lack the necessary receptors, common treatments like hormone therapy and drugs that target estrogen, progesterone, and HER-2 are ineffective,” the National Breast Cancer Foundation states on its website. Chemotherapy is often a triple-negative breast cancer patient’s only option. Weiping Zou, a renowned professor of surgery and pri- mary researcher in the study, explained the issue with cur- rent immunotherapy treat- ment. “Immunotherapy works very well for some patients, but not everyone is responsive to the treatment,” Zou said. “Through this study we hope to improve the current treatment to make it bet- ter for more people.” During the project, the researchers studied the tumors’ growth in mice, approved by the committee on Use and Care of Animals at the University of Michigan. They were able to mea- sure the growth of the tumors and find the factors that caused the processes within them. The researchers also studied culti- vated cells separately. Extensive measurements were taken during the experiment on tumor growth and cell production which were then analyzed using various data analytical techniques. Dr. Inka Kryczek, Research Assistant Professor of Surgery, summarized the various parts of the process they studied. “We looked at the metabolic pathways, the immunosuppres- sive cells themselves, and the biology of the tumor. It proved to be a very comprehensive study.” said Kryczek. The new research sheds some light on what could be causing the development of the immune suppressor cells. A link found between the metabolic produc- tion of glycolysis and the number of the immune suppressor cells present in the tumor showed a direct correlation between an increase in glycolysis and an increase in immune suppressor cells. Zou believes the discovery can lead to new treatments for patients that exhibit high num- bers of the immune suppressor cells. “We hope we can manipulate the metabolic pathways to devel- op an immunotherapy approach to help these patients,” Zou said. Zou also anticipates the research will inspire other researchers to develop better techniques for treatment.