Monday, July 16, 2007
The Michigan Daily - michigandailycom
'3
ALZHEIMER'S
From page 2
formed when proteins are converted
into a misfolded shape, and continue
converting other proteins, creating
a chain in a process that damages
surroundingbrain cells.
Chapman said the "self-perpetu-
ating reaction" that these fibers
engage in explains the rapid onset
of dementia and loss of cognitive
abilities from the time symptoms of
Alzheimer's are first seen.
"Once you get it started, you're
sort of up the creek," he said.
Now that Chapman has discov-
ered fiber production in bacteria,
researchers can begin to investigate
what sets off the condition.
Chapman said that while the fiber
formation process is more compli-
cated in humans, researchers will
be able to understand it better by
observing the process in bacteria.
Chapman said that while it is
advantageous to bacteria to produce
amyloid fibers, it is unclear what
prompts the production of the fibers
in humans and why it is harmful.
Answering those questions could
revolutionize the way Alzheimer's is
treated, Chapman said.
While amyloid fiber formation
has been considered a toxic process
associated with disease for decades,
Chapman has hypothesized that
forming amyloids is not always bad.
Chapman's bacteria have shown
him that the fibers produced as the
end result of the process are not
harmful to the cell, but rather the
process itself.
Many treatments being
researched for Alzheimer's disease
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attempt to slow down the process
of fiber formation, but Chapman
said doing so might lengthen the
time that cells are at risk of being
damaged.
"Instead, look for things that
facilitate that process, that would
lessen the toxicity," he said. "In
bacteria, we can show that we can
skip over the toxic steps by pro-
viding facilitator proteins."
Theresearchfindings,authored
by Chapman, Rackham graduate
student Neal Hammer and Jens
Schmidt, a visiting student from
Germany. were published online
lastweekinthe Proceedingsofthe
National Academy of Sciences.
ADIDAS
From page 1
with the 2007-2008 season.
Jason Winters, the athletic depart-
ment's chief financial officer, said the
extra funds will go toward renovating
athletic facilities like Chrysler Arena.
Adidas approached the University
with a proposal after Nike's exclusive
negotiation rights expired in Febru-
ary, Winters said.
Winters said the offer Nike present-
CORRECTIONS
Please report any error in the Daily
to corrections@michigandaily.com.
ed during resigning negotiations
"wasn't exciting." He said Nike
then declined a chance last spring
to maintain its partnership with the
University by matching Adidas's
bid.
"We received a proposal from
Adidas that we were very comfort-
able with," Winters said. "Adidas
showed they were going to be a lot
more flexible in contract terms."
Beyond financial matters, Win-
ters said the agreement with Adi
das grants the department more
individual attention and control
over the deal's operations.
Athletic Director Bill Martin said
the look of teams' attire - espe-
cially Michigan football uniforms
- will change little or not at all. He
said Adidas will allow the Univer-
SeeADIDAS, Page 8
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