LOCAL/STATE
The Michigan Daily -- Thursday, March 22, 2001 - 3A
RESEARCH
New antibiotic
inhibits enzymes
College of Pharmacy researchers have
found an unknown family of metal-
requiring enzymes in bacteria, the result
ofanewly discovered potential antibiotic
inhibits enzymes of the family
Led by pharmacy Prof. Ronald
Woodard, researchers found that the
inhibitor PD 404182 was 10,000 times
more effective than any other in
inhibiting an enzyme in the bacteria,
called Gram negative bacteria. The
enzyme KDO 8-P synthase plays a
necessary role in forming lipopolysac-
charides on the surfaces of the cells of
bacteria, which help the organisms
protect themselves from harmful bod-
s,-including antibiotics and host
une responses.
By targeting KDO 8-P synthase,
researchers from the college and
Wayne State University School of
Meudicine determined the crystal struc-
ire of the enzyme using E. coli bacte-
ria; Researchers could not observe the
inhibitor binding to the enzyme's
active site because of the high salt con-
entration in the holding solution
Wterfering with binding.
Instead, the enzyme was isolated
and crystallized in a bacterium called
Aquifex aeolicus, which .lives at high
temperatures, allowing researchers to
introduce substrates at lower tempera-
tures without completing the reaction.
Through this process, eight interme-
diate structures of KDO 8-P synthase
were found, showing the necessary
steps of its catalytic cycle.
The group also found that the
*nzyme requires metal to function, and
it is unaffected by the potential antibi-
otic called PD 404182.
The researchers work appeared in
the March 16 issue of the Journal of
Biological Chemistry.
Online shopping
on the rise
* Rather than leaving home, a grow-
ing. number of shoppers are choosing
to buy their groceries online, accord-
ing to a study at the University of
Georgia.
The study, led by Prof. Brenda
Cude, the chair of the Housing and
C -onsumer Economics Department,
found that only 14 percent of 243
shoppers had purchased groceries
online during their first survey, where-
43 percent had in their second sur-
ieyof412 shoppers.
When asked if people would be
.willing to buy all of their groceries
online, 48 percent of the people origi-
nal surveyed said yes and 79 percent
supported the idea in the second.
By surveying people after they com-
.pleted online orders, the study found
that people were most concerned with
buying meat and fruit products online,
*nd that 30 percent of them said they
had previously shopped at a large,
competitive grocer.
The group will present its findings
on.April 5 at the American Council on
Consumer Interests' annual meeting.
Half of Americans
think they've had
a mid-life crisis
9, Researchers at Cornell University
believe that more than half of the 25
: cent of Americans over 35 who
think they have experienced a mid-life
Zriis are only dealing with a stressful
ievent in their lives, and that women are
just as likely as men to believe they
hive had a mid-life crisis.
Human development Prof. Elaine
Wethington conducted the research,
*which consisted of 724 follow-up sur-
veys of people between the ages of 28
1n 78 years old as part of a larger
'tfdy, titled "Mid-life in the United
States."
Brought on by fears and anxieties
of aging, a mid-life crisis bases
itself on personal turmoil and deal-
ing with challenges in people rang-
-,ing from 39 to 50 years old, yet
Wethington's research showed that
most people report stressful events
which occurred before age 39 or
after age 50. The average age of the
perceived crisis in people survey was
46. 20 percent of these people said
they suffered a crisis because of their
awareness of their aging, where few
felt the feelings were caused by the
though of impending mortality.
- Compiled by Daily Staff Reporter
Lisa Hoffman.
Nerves of steel
oenracan rof.talks
on race, militarism
By Courtenay Basile
For the Daily
Members of the history department
gathered yesterday in Tisch Hall for a
lecture on German colonialism and race
relations delivered by Prof. Pascal
Grosse of Humboh University in Berlin.
Grosse's lecture, titled "The Milita-
rization of 'Race' and the Racialization
of the Military: The German Experi-
ence," was sponsored by the history
department and allowed students and
faculty to learn about German colonial
politics and the racial order of the mili-
tary between 1910 and 1925.
Focusing on the racial sentiment of
the German military regarding the mili-
tary makeup of other European nations
pre-World War I, Grosse said, "Germans
believed themselves to be the only true
defenders of the white race." He went on
to explain this in the context of his stud-
ies of colonial migration from Africa to
Germany in the late 19th century.
Grosse geared his discussion toward
three main topics: the reaction of Ger-.
mans to the Allied use of colonial sol-
diers, the policies within German
prisoner of war camps and the relation
between the occupation of the Rhineland
and post-war politics of Germany.
He explained that the Black Threat,
the use of black colonial soldiers from
Africa, and the way in which the colonial
soldiers were treated, were symbols of
the German brutality in the coming war.
"Non-whites were frowned upon,"
Grosse said.
Grosse actively engaged the audience
in discussion of the Allied European
policies versus German policies. He 4is-
cussed the ongoing conflicts of defining
the term "race." The questions posed to
Grosse by the audience, consisting most-
ly of graduate students and profess rs,
reflected their obvious interest in Jhe
material presented.
"German warfare has always beenan
avid interest of mine. When I heard the
topic that Professor Grosse was spealng
on from a friend, I was really interejed
in hearing a German perspective," Eiigt-
neering sophomore Eric Mattson said:
Grosse, who trained in history 'nd
medicine at the University in Berlin, eur-
rently is continuing his medical studies
at the Institute of Neurology in London,
SAM HOLLENSHEAD/Daily
Chad Bowerson holds onto a rail wire while working on the new Haven Hall yesterday. The iron workers expect to
complete the new steel frame for the building tomorrow.
Students say need to
have a car outweighs
costs o fp arking fines
Upcoming
Events
M=C For information on all Michigan Athletics, visit MGoBlue.corn
PARKING
Continued from Page 1A
or outstanding parking tickets and
students contribute significantly to
the city's revenue.
Edwards said at one point she had
six outstanding parking tickets but
only let a few weeks go by without
paying them.
"It just happens today I got one,"
Edwards said yesterday. "I put quar-
ters in the machine and it didn't
work. The time didn't go up. I just
left my car since I was late for an
exam."
LSA freshman Mark Worthley
uses the lot in front of Mary Markley
Residence Hall, and said despite the
parking tickets he's received, it's nec-
essary to have a car because he lives
out of state.
"Everyone wants to have cars to
drive home for the weekend," he
said.
City Administrator Neil Berlin
said Ann Arbor currently has one
employee who surveys license plates
for outstanding parking tickets and is
not planning to hire any additional
staff.
MILES
Continued from Page 1A
sors might not be assigned to teach
his classes immediately and that they
would not be offered.
"Students would not have an
opportunity to take it and I had no
indication that the course would go
under another teacher," Miles said.
Students have planned a reception
tomorrow night at 8 p.m. in the
Chrisler Auditorium on North Cam-
pus to honor Miles for his service to
the University community.
Zakiya Franklin is one student
who will be honoring Miles. She
said his in-depth lectures and his
willingness to drive so far to teach
his classes have made her respect
him as an educator.
"He makes a two hour lecture very
interesting. His speaking method is
what caught me the most," Franklin
said.
Miles said he treks from Chicago
every week because he feels teaching
is a way to repay the University.
As a graduate student with a wife
and two children, Miles said he did
not have enough money to put him-
self through college.
"The University was very gener-
ous in offering me scholarship assis-
tance," Miles said. "I just see
(teaching) as a way to give back to
the University that was so kind to
me."
Miles also said learning about reli-
gion is an important part of an edu-
cation, because it helps people
understand culture.
"I feel religion has played a pow-
Ticketing employees also have the
power to impound a vehicle if they
find while writing a ticket that the
car already has several outstanding,
Scott said.
In February 2000, 98 cars were
towed as a result of outstanding
parking tickets, with that figure
increasing to 178 by March, accord-
ing to city parking statistics. State
law dictates that a car can be towed
after accumulating six or more out-
standing tickets, Scott said.
"The city of Ann Arborhas gone
to a system where we have gotten a
writ of execution and can tow after
four or more," Scott said. The city
was able to ask for this writ as a
result of its population size and park-
ing capacity. Scott said the Main
Street area is a major ticketing area
because of shorter time limits on
meters.
In order to retrieve a car after it
has been towed, outstanding tickets
and an administration fee must be
paid in full at the police department.
"They have to go to the towing
company to have their vehicle
released and pay the towing
charges," Scott said.
erful role in the lives of people.
Religion has impacted the develop-
ment of public schools, has shaped
the way our country does business
with other countries. One can not
really understand the role of the
African American experience with-
out understanding their religion,"
Miles said.
Marlon Ross, associate director of
the Center for Afro-American and
African Studies, said that both his
program and the religion program
are looking at ways to expand cours-
es that professors such as Miles have
started at the University.
"This is a beginning of a much
more broad effort," Ross said.
Miles said that his class is not a
requirement for any concentration
but that the class always has the
maximum number of students regis-
tered.
"Students who take my class learn
a lot about an area that most people
don't study. They heard that we had a
good class. They found that the sub-
ject matter gripping. We talk about
how some of the things fold into
other areas of life. Every time I
come to Michigan I try to do the best
I can, to really give a great lecture,"
Miles said.
Miles said that he has no ill feel-
ings toward the University for asking
him to leave.
"I'm always going to be a Michi-
gan supporter. It was the University's
right to do this. I'm not egotistical
enough to say no one else can teach
what I did," he said. "I'm a little
sorry about the classes that will take
a while to build back up."
Friday, March 23
#3 Michigan vs. #5 Sonoma State
#2 Colorado State vs. #18 Texas
Saturday, March 24
#5 Sonoma State vs. #18 Texas
#3 Michigan vs. #2 Colorado State
Sunday, March 25
#2 Colorado State vs. #5 Sonoma State
#3 Michigan vs. #18 Texas
r-2 0 0 1 -
6:00 p.m.
9:00 p.m.
5:00 p.m.
8:00 p.m.
3:30 p.m.
7:00 p.m.
Oosterbaan Fieldhouse (off State Street behind Schembechler Hall and Yost Arena)
Admission (at the door only): $2 for UM students/staff (with ID), $4 for general public
-V
Exciting Promotions
* Free T-shirt toss after every UM goal f
* Free posters to first 200 fans every night
o Halftime shooting contest with prizes!
lie] c
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Join us and contribute to a world-wide community
service effort.
UJC represents and serves one of the
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What's happening in Ann Arbor today
EVENTS
S Undergraduate English
Seventh Annual Poster
Contest and Exhibition
Award Ceremony, Spon-
--r- ki,- Cn in of-
Latin American and
Caribbean Studies, Alejan-
dro Herrero-Olaizola will
cno l- nnn '?OQ fiWR
SERVICES
Campus Information
Centers. 764-INFO.
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