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• Disc Herniations
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SPINAL DECOMPRESSION SPECIALISTS
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Jerusalem Post
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*Phone Consultations Available
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This item appeared originally in the
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Only
echnion-Israel Institute of
Technology scientists have
developed a new material
with the potential to treat hundreds of
genetic diseases.
The material was created by
Professor Timor Bazov of the chem-
istry faculty along with Dr. Tamar
Ben-Yosef of the Rappaport School
of Medicine. The two published their
discovery recently in the journal
Bioorganic and Medical Chemistry
Letters.
"In every cell there are ribosomes,
which are a kind of 'machine' that
translates the genetic information for
the protein," Bazov said. "The mate-
rial we developed, called NB30, binds
to human ribosomes, and in a place
where there is a mutation that cre-
ates a halt in the 'translation' of the
protein, it places an amino acid that
makes possible the continued 'transla-
tion' until the production of an active
protein."
Bazov has worked for years on
a family of antibiotic drugs called
aminoglycosides, which work against
a broad range of bacteria. As some
bacteria have developed resistance
to certain types of antibiotics, Bazov
is studying the mechanism for this
resistance.
"One of the problematic ones is
pseudonomas, which is much more
resistant than the klebsiella," which
received much publicity recently
in the media, he said. "It especially
attacks patients with weak immune
systems. We have developed antibiotic
materials against pseudonomas," he
said.
"In 2003, I met Professor Eitan
Kerem of Hadassah-University
Medical Center who told me that half
of cystic fibrosis patients die from
infections caused by the bacterium:'
Bazov said. "Kerem proved that the
antibiotic gentamycin can correct
a defective gene in CF patients and
help them a lot. The problem is that
it has to be given to these patients at
very high dosages, but this can hurt
patients and even kill them!'
The Technion team took gentamy-
cin, made a chemical modification
and created a new material that is able
to correct a defective gene and is less
than one-seventh as toxic as genta-
mycin.
"The new material has the potential
to help cure hundreds of genetic dis-
eases:' Bazov said, "and perhaps even
certain types of canceC
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