8

Thursday, June 14, 2018
The Michigan Daily — michigandaily.com
NEWS

1014 VAUGHN AVAIL Fall 2018

#1 is being rented by the room for 

$700/m including utilities

If you have a group of 5, rent the whole 

unit for $3100 plus Electric to DTE

#2 is a 6 Bdrm for $3720 plus Electric 

to DTE • 734‑996‑1991

1015 PACKARD

4 Bdrm Apt Avail Fall 2018

2 parking space, onsite laundry, 1st 

floor

$2830 + Electric to DTE • 

734‑996‑1991

\

422 HAMILTON

2 & 3 Bdrm Avail Fall 2018

#2 ‑ 3 bdrm ‑ 2nd floor ‑ $2350

#3 ‑ 2 bdrm ‑ 3rd fl ‑ $1550

Tenants pay gas and electric to DTE

Showings M‑F 10‑3 • 734‑996‑1991

CENTRAL CAMPUS, FUR-

NISHED rooms for students, shared 

kitch., ldry., bath., internet,

 rent from $700 and up. Call 

734‑276‑0886.

HOUSES AVAILABLE FALL 2018

1016 Packard ‑ 4/6 Bdrm ‑ 

$3080‑$4020

401 Pauline ‑ 4 Bdrm ‑ $2900

827 Brookwood ‑ 4 Bdrm ‑ $2900

Showings M‑F 10‑3 • 734‑996‑1991

FOR RENT

Classifieds

Call: #734-418-4115
Email: dailydisplay@gmail.com

 
 
 

1014 VAUGHN AVAIL Fall 2018
#1 is being rented by the room for 
$700/m including utilities

Classifieds

Call: #734-418-4115
Email: dailydisplay@gmail.com

ACROSS
1 Common
borrowing result
5 Add one’s two
cents, with “in”
10 “So that’s what
that means!”
13 Novelist 
John le ___
15 Resort near Vail
16 “Hansel and
Gretel” figure
17 Pigmented eye
parts
18 Devour, with
“down”
19 Outback bird
20 Longtime
network symbol
22 Historical display
24 Lucy’s co-star
25 Sandal features
26 Hardly helpless
28 Solemn oath
30 Subj. that may
include a lab
31 Potting need
32 Skater who lit the
Olympic cauldron
in Nagano
33 Responses from
a sycophant
36 Refine
37 House of __
39 Student stressor
41 Cut even shorter,
as a green
43 Loophole
44 Times in
classifieds
45 “Bambi” doe
46 A
47 Small deer
48 Not a good fit
51 Heavy hammer
53 They’re run in
taverns
54 Standoffish
57 Cracker lacking
pop
58 Producer Scott
with Emmy,
Grammy, Oscar
and Tony wins
60 Tsar’s decree
61 Mimic
62 Poker declaration
63 Private student
64 Strong desire
65 Spot __
66 Scorch

DOWN
1 Bra spec
2 Holiday lights
may be under
one
3 Depression Era
sight
4 Cobalt in the
human body, e.g.
5 Wine container
6 TV buying
channel
7 Apple Store buys
8 Promotion criteria
9 Carry out, as
laws
10 Lots
11 Actor Jon and
others
12 Rio contents
14 Those, in Tijuana
21 Certain 19th-
century history
specialist
23 Cause
commotion ... or
what the circled
letters do?
25 Smallish, as an
apartment
26 Tapped-off
remnant
27 Uncouth sort

29 Oklahoma people
34 Use a micro-
dermabrasion
agent, say
35 Make fully
content
38 Hound for
payment
40 Submissions to
eds.
42 Quebec neighbor
48 Brownish gray

49 Elizabeth of
beauty products
50 FAA overseer
52 Été month
53 Gift-giving
occasion, for
short
54 Shave-haircut
link
55 No longer in port
56 Not a good look
59 Land in la mer

By Joe Kidd

©2018 Tribune Content Agency, LLC
06/14/18

06/14/18

ANSWER TO PREVIOUS PUZZLE:

RELEASE DATE– Thursday, June 14, 2018

Los Angeles Times Daily Crossword Puzzle

Edited by Rich Norris and Joyce Nichols Lewis

CHECK OUT OUR COOL

www.michigandaily.com

WEBSITE.

NOW.

New cancer study 

U-M researcher’s 
discovery leads to 
potential improvement 
of cancer therapy

By ROB DALKA

Daily Staff Reporter 

Researchers at the Univer-
sity of Michigan Rogel Cancer 
Center have determined cancer 
cells seize control of the meta-
bolic pathways within specific 
immune cells to suppress the 
immune system and accelerate 
tumor growth.
Immune suppressor cells that 
exist in cancerous tumors block 
the body’s natural defense sys-
tem, and a high volume of these 
immune suppressor cells can ren-
der the immune system ineffec-
tive at fighting tumor growth.
Previously, researchers had lit-
tle understanding of what caused 
the development of immune sup-
pressor cells but did recognize 
the necessity of a healthy immune 
system in the battle against can-
cer. Immunotherapy, which har-
nesses a patient’s own immune 
system to fight cancer, has been 
very successful for survivors of 
certain cancers.
“Immunotherapy 
includes 
treatments that work in differ-
ent ways,” the American Can-
cer Society states on its website. 
“Some boost the body’s immune 
system in a very general way. 
Others help train the immune 
system to attack cancer cells spe-
cifically.”
The 
limited 
understand-
ing of the immune-suppressing 
cells makes it difficult to treat 
certain types of cancers using 
immunotherapy. Cancers, such 
as triple-negative breast cancer 
– the cancer cell line used in this 
research because of its prominent 
immune suppressor cells – are 
especially difficult to treat. Tri-
ple-negative breast cancer lacks 
three common receptors that 
stimulate tumor growth, making 
it harder to treat.
“Since the tumor cells lack the 
necessary receptors, common 
treatments like hormone therapy 
and drugs that target estrogen, 
progesterone, and HER-2 are 
ineffective,” the National Breast 
Cancer Foundation states on 

its website. Chemotherapy is 
often a triple-negative breast 
cancer patient’s only option.
Weiping Zou, a renowned 
professor of surgery and pri-
mary researcher in the study, 
explained the issue with cur-
rent 
immunotherapy 
treat-
ment.
“Immunotherapy works very 
well for some patients, but not 
everyone is responsive to the 
treatment,” Zou said. “Through 
this study we hope to improve the 
current treatment to make it bet-
ter for more people.”
During 
the 
project, 
the 
researchers studied the tumors’ 
growth in mice, approved by 
the committee on Use and Care 
of Animals at the University of 
Michigan. They were able to mea-
sure the growth of the tumors 
and find the factors that caused 
the processes within them. The 
researchers also studied culti-
vated cells separately. Extensive 
measurements were taken during 
the experiment on tumor growth 
and cell production which were 
then analyzed using various data 
analytical techniques.
Dr. Inka Kryczek, Research 
Assistant Professor of Surgery, 
summarized the various parts of 
the process they studied.
“We looked at the metabolic 
pathways, the immunosuppres-
sive cells themselves, and the 
biology of the tumor. It proved to 
be a very comprehensive study.” 
said Kryczek.
The new research sheds some 
light on what could be causing 
the development of the immune 
suppressor cells. A link found 
between the metabolic produc-
tion of glycolysis and the number 
of the immune suppressor cells 
present in the tumor showed a 
direct correlation between an 
increase in glycolysis and an 
increase in immune suppressor 
cells.
Zou believes the discovery 
can lead to new treatments for 
patients that exhibit high num-
bers of the immune suppressor 
cells.
“We hope we can manipulate 
the metabolic pathways to devel-
op an immunotherapy approach 
to help these patients,” Zou said.
Zou 
also 
anticipates 
the 
research 
will 
inspire 
other 
researchers to develop better 
techniques for treatment.

