8
Thursday, June 15, 2017
The Michigan Daily — michigandaily.com
NEWS
ACROSS
1 Port initials
4 Fallon’s
predecessor
8 Negative quality
13 Late July arrival
14 No longer hung
up on
15 Composed
16 Going rate?
18 Younger
daughter of Hi
and Lois, in
comics
19 Admission of
defeat
20 Petal pusher?
22 Baseball’s Wills
and TV’s Povich
24 __ zone:
shallowest
oceanic region
that sunlight
doesn’t reach
27 Co. once led by
Baryshnikov
28 Sap sucker
31 Green prefix
32 Suffix with Bieber
34 Like aged
cheddar
36 With some
unscrambling,
the contents of
each set of
circles
40 Invoice word
41 Blow one’s fuse
42 Once-sacred
snake
43 Straight sides of
a pizza slice, e.g.
45 Relaxation
destination
48 Low-down
prank?
51 __ torpedo: “Star
Trek” weapon
54 Symbol of
complementary
principles
57 Watching intently
58 Bakery-café
chain
60 Man of steel?
62 “Wild” author
Strayed
63 Actor Baldwin
64 Tillis of country
65 “Sonatine
Bureaucratique”
composer
66 Soothing
succulent
67 Pitches during
breaks
DOWN
1 Word’s last syllable
2 Aquanaut’s base
3 Block during
rebounding, in
basketball
4 Up in the air
5 Actress Longoria
6 Soft toy brand
7 Russian city
where Turgenev
was born
8 Positive quality
9 “Fighting” Indiana
team
10 When some fans
have to wait till
11 Solitary prefix
12 “Told you!”
15 Fine fiddle
17 Med. nation
21 Sapporo sash
23 Reasonable
25 Zoning unit
26 Cut
29 Shot
30 Word repeated
twice in a Roger
Ebert title about
bad movies
32 Injured pro’s test,
perhaps
33 Toward the stern
34 “What’s doin’?”
35 Haberdasher’s
item
36 Latin American
capital
37 Like some late-
game hockey
goals
38 Hindu title
39 Wisecrack
40 Fan sound
43 __ blue
44 Words with clip
or crossroads
45 Mark of shame
46 Paid (up)
47 Cloud dwellers?
49 Guy in the kitchen
50 Deli order
52 For this reason
53 “Listen up,” to
Luis
55 Indiana-based
sports org.
56 Chutzpah
58 Best Buy buys
59 “That’s it!”
61 Flying Cloud, for
one
By Brian Thomas
©2017 Tribune Content Agency, LLC
06/15/17
06/15/17
ANSWER TO PREVIOUS PUZZLE:
RELEASE DATE– Thursday, June 15, 2017
Los Angeles Times Daily Crossword Puzzle
Edited by Rich Norris and Joyce Nichols Lewis
xwordeditor@aol.com
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Anti-Zika pesticide linked to slowed brain growth
By CHETALI JAIN
Daily Staff Reporter
Since the alarming incidences of
the Zika virus in North and South
America in 2015, efforts to study
the formidable infectious agent
and find ways to prevent its spread
have intensified. Researchers at the
University of Michigan conducted a
study to investigate the link between
exposure to pesticides like naled and
chlorpyrifos — which are used to kill
mosquitoes that could potentially
be carrying the virus — and child
neurodevelopment.
The virus, which is transmitted to
humans via a mosquito vector Aedes
aegypti, has been linked to serious
neonatal malformations as well
as Guillain-Barré syndrome — an
autoimmune disease which leads
to nerve damage and weakness in
adults.
John Meeker, an Environmental
Health Sciences professor in the
School of Public Health, oversaw the
project that built on earlier studies
done by Betsy Lozoff, Center for
Human Growth and Development
professor, and her research team.
“There has been a lack of
human research on naled, whereas
chlorpyrifos has been more well-
studied but not for these effects
specifically,” Meeker said.
The
statistically
significant
results of the University study
showed there were issues with
motor skill development in infants
that were prenatally exposed to
the
aforementioned
insecticide
chemicals.
According to Monica Silver, a
research fellow at the School of
Public Health, naled exposure is
associated with fine motor function
deficits,
notably
visual-motor
coordination, while those exposed
to chlorpyrifos exhibited deficits in
both gross and fine motor functions.
Silver acknowledged the delicate
balance between stopping the spread
of the virus and avoiding the adverse
effects of such preventive measures.
“Zika is a very serious public
health threat, but this study
highlights that the way we go
about combating Zika and other
vector-borne
diseases
needs
to be carefully thought out in
order to minimize unintended
consequences,” Silver said. “One
of the aims of my research was to
examine the effects of prenatal
organophosphate
insecticide
exposure on infant motor function.”
Currently,
the
U.S.
Environmental Protection Agency
regulates the use of both insecticide
chemicals. Chlorpyrifos is the
most common way to control
agricultural pests. However, the
United States no longer licenses
the chemical due to its propensity
for causing neurotoxic damage.
The study was innovative in
its incorporation of the potential
ecological
effect
to
Lozoff’s
study
of
iron
deficiency
and
neurodevelopment.
“This is an example where we
leveraged NIH funding by building
an environmental exposure study
on top of a nutrition study,” Lozoff
said.
Future
directions
shared
among the researchers include
a
shift
toward
studies
that
examine
different
ways
to
control the spread of Zika while
simultaneously taking into account
the unintentional costs of doing so.
“Holistic approaches addressing
the full spectrum of the issue to
reduce Zika-carrying mosquito
populations,
mosquito-human
interactions, and mosquito bites
should be considered in order to
minimize both the spread of the
virus and the amount of potentially
harmful chemicals used,” Meeker
said.
Investigators hope that their
research exposing the detrimental
effects
of
the
chemicals
on
neonatal health will encourage
future studies to focus on the
impact of such pesticide usage
on the environment and human
health.
FILE PHOTO/DAILY
The University of Michigan School of Public Health