with normal cells in the same
individual.
“The basic idea is, based on a
patient’s molecular fingerprint,
to suggest clinical trials or off-
label use of approved agents
based on the mutational profile
of
an
individual
advanced
cancer, or, in general, metastatic
disease,” Chinnaiyan said. “By
matching a patient’s molecular
fingerprint with potential drugs
that target those aberrations, we
have a better chance at treating
cancer in a precise or rational
fashion.”
The University is licensing
the MI-ONCOSEQ panel to
Tempus. Clo Ewing, director
of communications at Tempus,
wrote in an email interview that
the health-tech company aims
to commercialize the genomic
panel and provide access to
clinicians
and
health
care
specialists nationwide.
“Our
partnership
with
University of Michigan will allow
patients across the country to
benefit from clinically validated
technology that UofM has been
developing for years,” Ewing
wrote. “Combined with our
interactive analytic and machine
learning platform will support
physicians across the country
working to deliver personalized
cancer care.
Chinnaiyan
noted
that
because each cancer has unique
molecular
characteristics,
genetic sequencing of tumors
can provide physicians evidence
for decision-making in treatment
methods.
“For example, not all breast
cancers are the same,” he said.
“They are caused by different
gene aberrations and knowing
those in a more precise fashion,
we hope that we will be able to
deliver more durable therapies
for cancer patients.”
He added that the previous
treatments for cancer such as
chemotherapy
and
radiation
were relatively non-specific.
“While you attempt to try and
hit cancer cells, you often hit
normal cells as well,” he said.
Since 2011, MI-ONCOSEQ has
been utilized for more than 1,500
patients, sequencing between 12
and 25 patients a week.
Chinnaiyan also explained
that MI-ONCOSEQ is reasonable
in
cost
and
turnaround
time
for
delivering
results.
Previous approaches to genome
sequencing
had
an
average
turnaround time six to eight
weeks, whereas MI-ONCOSEQ
takes about 10 days.
With the shifting paradigm
in
personalized
medicine,
MI-ONCOSEQ allows clinicians
across the country to provide
personalized
cancer
care.
Costs for genome sequencing
have
significantly
decreased
over the past decade, making
it
more
affordable
and
accessible, according to Ewing.
Simultaneously,
technological
advancements allow for larger
quantities of data analysis.
“Together, this means we are
at a point in time where we can
empower physicians to make
real-time, data-driven decisions,
which we hope will result in
more time for people living with
cancer,” Ewing wrote.
The
unique
partnership
between the University and
Tempus is facilitated by the
close
relationship
between
Chinnaiyan and the health-tech
company’s laboratories.
Furthermore,
the
collaboration extends beyond
just the panel.
“We work closely with
Arul as he has agreed to
become a scientific advisor
to Tempus,” Ewing wrote.
“We’ve developed a very
close
relationship
with
our labs cooperating on an
almost daily basis.”
Chinnaiyan said he sees
patients for MI-ONCOSEQ
after
they
have
failed
multiple other treatments,
at which point the cancer
is evolved and difficult to
treat.
“I think, moving into
the future, the hope is
that this technology of
comprehensive
molecular
analysis of tumors, basically
this
next-generation
sequence
analysis,
will
be
brought
to
earlier
stage
cancer
patients,”
he
said.
“By
matching
that combination of gene
alterations with the right
combination of treatment,
we hope to be able to achieve
more durable responses for
cancer patients.”
The undefeated, third-
ranked Michigan football team
may have had a bye-week this
past weekend, but head coach
Jim Harbaugh certainly wasn’t
taking it easy.
On a recruiting trip to
El Cerrito High School in
California, Harbaugh attended a
football game and worked on the
‘chain gang’ — assisting officials
with the down markers — in
exchange for a steak sandwich,
the Detroit Free Press reported.
“The chain gang needed
a guy and I was promised
a tri-tip steak sandwich at
halftime, that’s all I needed
to hear,” Harbaugh said on
Monday during his weekly press
conference. “That was a lot of
fun.”
Known for his unusual
recruiting trips, Harbaugh has
had sleepovers and climbed
tees in the past in attempts to
impress prospects. On this trip,
Harbaugh visited four-star
outside linebacker recruit Aaron
Banks at El Cerrito High. He
also announced the homecoming
queen on Friday at Antioch High
School in California where he
was visiting the top prospect in
the country, running back Najee
Harris, ESPN reported.
Harbaugh’s enthusiasm for
steak is also well documented.
He posted a picture of himself
and wife Sarah on twitter at
Ruth’s Chris Steak House in
Ann Arbor last week, after a
promotion gave customers a
percentage off their final bill
based on the Michigan football
team’s margin of victory.
Michigan defeated Rutgers
78-0, the largest margin of a
victory since 1939, meaning the
steakhouse offered customers
the maximum of 50 percent off
their bills during the following
week.
“Ruth’s Chris & Buzz Goebel!
Sarah, me & Ann Arbor thank
U for being such good sports!
Plus the Steaks are A++, Mercy!,”
Harbaugh’s tweet read.
BACK TO THE GRIND.
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2A — Wednesday, October 19, 2016
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CAMPUS EVENTS & NOTES
Poetry Slam Night
WHAT: UM Poetry Club will
co-host an amateur poetry
slam night with cash prizes,
in conjuction with a special
Museum of Archaeology exhibit.
WHO: Kelsey Museum of
Archaeology
WHEN: 7 p.m. to 9 p.m.
WHERE: Kelsey Museum of
Archaeology
Guatemala Birding Talk
WHAT: Lecture by Washtenaw
Audubon Society about the group’s
recent bird-watching trip to
Guatemala.
WHO: Matthaei Botanical Gardens
& Nichols Arboretum
WHEN: 7:30 p.m. to 9 p.m.
WHERE: Matthaei Botanical
Gardens
Swing Dancing
WHAT: Opportunity for
interested students to check out
swing dancing and meet new
people.
WHO: Student Organizations:
Mswing
WHEN: 8:30 p.m. to 10 p.m.
WHERE: Michigan League,
Room D
Presidential Debate
Viewing
WHAT: Viewing open to
students and faculty of the final
presidential debate, sponsored
by the Department of Political
Science.
WHO: Undergraduate Political
Science Association
WHEN: 9 p.m. to 10:30 p.m.
WHERE: Palmer Commons
U.S.-China Economic
Relations Lecture
WHAT: Former World Bank
Chief Economist Justin Lin
and Ford Prof. John Ciorciari
to give lecture on the future of
economic relations.
WHO: Gerald R. Ford School
of Public Policy
WHEN: 4 p.m. to 5:30 p.m.
WHERE: Weill Hall,
Annenberg Auditorium
Medical School
Interviewer Event
WHAT: Prospective students
will have the opportunity to
listen to and ask questions of an
interviewer from the University
of Michigan Medical School.
WHO: Student Organizations:
Sports Medicine Club
WHEN: 7 p.m. to 8:45 p.m.
WHERE: CCRB, Bickner
Auditorium
STEM Study Abroad
WHAT: Information session
for students to hear about study
abroad opportunities in science,
technology, engineering and
math.
WHO: Center for Global and
Intercultural Study
WHEN: 5 p.m. to 5:30 p.m.
WHERE: Undergraduate
Science Building, Room 1230
Law Day
WHAT: The Career Center will
host an event for prospective
law students to meet with
representatives from more than
100 different law schools.
WHO: Newman Academic
Advising Center
WHEN: 11 a.m. to 2 p.m.
WHERE: Michigan Union
ON THE DAILY: HARBAUGH JOINS ‘CHAIN GANG’
KEVIN ZHENG/Daily
Bonnie, a Ann Arbor resident, gets her face painted as part of the Harvest
Festival at Cobblestone Farm in Ann Arbor Tuesday.
FALL FESTIVITIES
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University OF Michigan. One copy is available free of charge to all readers. Additional copies may be picked up at the Daily’s
office for $2. Subscriptions for fall term, starting in September, via U.S. mail are $110. Winter term (January through April) is
$115, yearlong (September through April) is $195. University affiliates are subject to a reduced subscription rate. On-campus
subscriptions for fall term are $35. Subscriptions must be prepaid. The Michigan Daily is a member of The Associated Press and
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