THE MICHIGAN DAILY TUESDAY, OCT. 12, 1937 Eddy Searches For Substitute For Morphine; Director Of Study Reports 150 New Substances Found In Experiments In an attempt to prepare a non- habit forming substitute for mor- phine more than 150 new substances have been brought to light, it was! disclosed yesterday by the pharma- cology department. Dr. Nathan B. Eddy has been di- recting the study here for the past seven years. He said that no such ubstitute has yet been found among the 323 compounds investigated, but that a large number of important facts in the chemistry and pharma- cology of morphine have been dis- covered. Virginia Aids Study The University of Virginia is pre- paring the various compounds to be' tested; the pharmacology department here observes the physiological effects of the substances on animals; and the U.S. Public Health Service co- operates in the clinical study of the addicting properties. In the work here, it was found that3 some animals react better to certain effects of the drugs than others. For this, reason many animals are usedz in testing each compound.l Mice are the cheapest animals. Dr.l Eddy explained that they are used to discover just how large a dose will cause death. Cats are used to deter- mine the pain relieving properties1 and rats to measure the ability of the drug to cause sleep. Monkeys Are Used1 Monkeys are used to investigate~the habit-forming properties. Rabbits1 respond best in the matter of de- creasing frequency of respiration. For the intestinal effect (the usual ef-1 fect here is constipation) dogs are1 used. Many of the compounds tested here were derivatives of morphine,l substances which can be obtained from morphine itself, Dr. Eddy said. This line of investigation was handi- capped by the discovery' that prac-R tically all the morphi'e derivatives1 possess some of the undesirable prop- erties of morphine itself. New Compounds Made This led to attempts to prepare the7 new substances by synthesis aboutl a simple molecular "base," which re-7 sembles the "core" of the morphine1 molecule to some degree. It was in this work that a large number of' compounds were prepared that had never been made before. A number of these compounds, Dr.1 Eddy indicated, have a high degree of pain relieving power. "However, for one reason or another these syn- thetic substances are not yet suitable. for use in man." It is hoped that just as the intro- duction of the non-habit forming, novocaine decreased addition to co- caine, the result of the work here will reduce addition to morphine, Dr. Eddy said. - A New $10,000 Arthritis Clinic Dr. Jay Claims Rapidly Nearing Completion Here' Dental Caries Band Makes Hit Number Of Large Industries At Purple Tilt;! ?t To Hold Benefit n Research Is Made Possible By Grant From Horace H. Rackham Foundation' (Continued from Page 1) of the most important diseases, he said, for it ranks at the top eco- nomically with anyof the more fatal diseases, such as tuberculosis and! cancer, which heretofore have caused greater concern because of their high mortality rate. However, although seldom fatal, Pledges Total 494; Average 12 Per House Council President Advises Investigation To Uncover Cause Of Less Pledging (Continued from Page 2) Marino, William Mogel and Philip Stephenson. Phi Sigma Delta: Harvey Acker- man, James Berger, Sumner Cotton, Harold Epstein, Hartley Goldstein, Edmund Harris, Richard Klaus, George Nedler, Lester Persky, Ber- nard Sissman, Samuel Soloman and Jack Stahl, Howard Greenberg, Herb Raskin. , Phi Sigma Kappa: Robert Hamil- ton, Harold McGregor, Richard Ma- har, Richard Northway, John Sobe- sky, Laurence Smith, Ralph Clark, Harold Weekler and Robert Hartnett. Pi Lambda Phi: Stanley Botwinik, Irwin Clamage, Robert Cohl, Sheldon Ettinger, James Frankel, Richard Harmel, Bertram Lefkowich, Jerome Rusem and Sheridan Winkleman. Psi Upsilon: Marcus Arthur, Wil- liam Briggs, Henry Calcutt, Glen Callandar, Gordon Carver, Hugh Clayton, Jack Crosslay, Paul Durfee, John Haglin, Clarence Kleinschmit, John Kumler, Rex Latham, John Mc- Elfresh, George Miller, William New- ton, Donald Spencer and John Van Winkle. Sigma Alpha Epsilon: Quentin Baker, Robert Bogle, Robert Burke- halter, Arthur Davidson, Joseph Foote, Robert Hague, Raymond Ing- ham, Glen Kendall, William Kloep- pel, Robert Moorhead, Joseph Ohman, Miles Porter, Robert Roy, Carl Schlegel, James Schooley, Chandler Simonds, Henry Tuttle, Bennett Root, Richard Shetter, Thomas Holcomb and William Cannon. Sigma Alpha Mu: Julius Aisner, Robert Bieberstein, Bernerd Bloom, Robert Cohn, Arnold Dana, Leo Federman, Charles Handel, Mortimer Kohn, Harold Levinson, Richard Posmantur, William Simon, Milford Ungerman and Howard Weisberg. Sigma Chi: William Bigler, Edward Bragg, Peter Brown, William Coch- rane, William Collette, John Cory, Merton DeLancey, William Gambill, Frank Hook, George Hughes, Steven Johnson, Alvin Kelso, Charles Knapp, Douglas Knight, Edwin Lorig, Blan Lucas, Allan Markham, Talmus Markham, Joseph Mason, Herman Nordstrom, James Ogle, Robert Reut- ter, Robert Rimqke, John Shepard, James Wilkinson and Robert Shulters. Sigma Nu: Wayne Belles, Robert Bragg, William Buchanan, Kenneth Eckhardt, Arthur Fox, Harry Gibson, Jack Grant,Jack Merriweather and Clarence Foessler. Sigma Phi Thomas Aigler, Dallas Cameron, Philip Clapp, Gil Conger, James Hynes, Paul Johnson, Stephen Johnson, Robert King, Walter Lait- ner, Frederick Linselle, Verne Mark- ley, Neal Seegert and John DeVine. Sigma Phi Epsilon: Thomas Arm- strong, John Canavan, Franklin Clif- ford, Robert Cranston, Edward Har- rison, George Howard, Robert Lowert, Ben Munn, Bruce Smith and Edward Johnson. Tau Kappa Epsilon: George H. Boyce, Robert J. O'Brien, George Scott, Gordon Stumpf and John Winne, Jr. Theta Chii: Edward Clark, Law- renceCrawford, Edwin Deale, Samuel Henderson, John Overton, Jack Sul- livan, William Taylor, Francis Col- lins, Lowell Williamson and Karl Kessler. Theta Delta Chi: John Barr, Basil Edwards, Burns Huttlinger, Fred Lamb, Edward Martin, James Mona- han, Roger Muzzel, James Neilson, Paul Parks, Karl Schairer, William Sherzer, George Thomson and Gene White. Theta Xi: Vernon Applegate, Thomas Black, Philip Cavanaugh, William Carter, Philip Conley, John Harwood, John Henry, William Hep- pinstall, John Lamb, Harry Lynn, William Mayo, Thomas Nesbit, Ar- nold Mignery, George Rulison, John Sinclair, William Wood, Brooks Latt, Harvey Ellsworth. Triangle: Robert Bishop, Russell Carey, Earnest' Petersen and Steve Poleschuk. Trigon: . John Collman, Maurice Dalby, Wesley First, Richard Howard, Caused ByDie arthritis is no less disastrous, Dr. Freyberg believes, for the sufferers incapacitated are more numerous than those euffering from tubercu- losis, heart disease and cancer com- bined. In 1932, it was estimated: that there was a loss of 7,500,000 work-weeks with a monetary equiva- lent of $200,000,000 to those disabled by chronic arthritis. Arthritis, commonly known to the layman as rheumatism, is a painful, crippling disease of the joints for which medical science has, as yet, found no cure, he said. "Because the study of this disease has been so long delayed compara-1 tively little is known about it and! the large bulk of patients afflicted with arthritis have one or more types, the cause of which is entirely un- known.' DAILY OFFICIAL BULLETIN Continued from Page 4) 13, 8:15 p.m. "The Present Crisis in China's Affairs," Arno L. Bader. Not- ices have been sent to all members whose addresses are unchanged from last year. Student members should consider this notice as an invitation. Alpha Kappa Delta: The first regu- lar meeting will be held at the home of Prof. Arthur E. Wood, 3 Harvard Place on Wednesday, Oct. 13, at 7:45 p.m. Please be prompt. Pi Lambda Theta meeting Wednes- day evening at 7:30 p.m .in the Pi Lambda Theta Room of the Univer- sity Elementary School. Members are urged to be present. Plans for the programs for the coming year will be discussed. The University of Michigan Radio Club will hold its first meeting of the year Oct. 13, 7:30 p.m. in Room 318- 20 Union. The club invites every one having an interest in radio communi- cation. Alpha Nu: On Wednesday evening, Oct. 13, Alpha Nu will hold an open meeting to which all freshmen and new men on the campus are cordially invited to attend. We wish to acquaint you with the program of Alpha Nu and at the same time get acquainted with you. Some of those attending will later be invited to join this hon- or society. The program will consist of a dis- cussion of a talk by Prof. Harold Dorr on the subject, "Mr. Black's Ap- pointment to the Supreme Court." Prof. Dorr is an able person to dis- cuss this very important subject and his discussion will be very interesting to all. The members of Alpha Nu will be expecting to see the freshmen and other friends in the chapter room on the fourth floor of Angell Hall at 7:30 p.m. Wednesday evening. Reserve Unit Names Cadet Officers Here (Continued from Page 1' I (Continued from Page 1) More Than 5,000 Nurses, (Co__1_.___ ro_- Page 1) Physicians, Educators Liam D. Revelli, of the School ysic, director of the band. of Mu-I Hear Dentist Lecture Rampant dental caries (ulceration of bone) can be effectively treated by restricting the carbohydrate in the diet, Dr. Phillip Jay of the School of Dentistry told more than 5,000 physi- cians, health officials, educators and nurses in attendance at last week's conference of the American Public Health Association. He questioned the popular belief that dental caries is a manifestation of malnutrition, declaring that there was no use in adding mineral and vitamin preparations to food to avert tooth decay. Caries Is Germ Caused In Dr. Jay's opinion, caries is a germ-caused disease in which Lacto- bacillus-acisdophilus played an im- portant part. The number of these germs in the mouth is determined by amount of sugar and starch (carbo- hydrates) eaten. Dr. Jay referred skeptics to a children's home in Ohio. "Only eight per cent of the 300 children there suffer from tooth de- cay, a remarkable achievement inI comparison to the average of 95 per cent among children," he said. No refined sugar in any form is given these children, he added. Back in Ann Arbor for a week be- fore leaving for Texas this Saturday, Dr. Jay elaborated on newspaper re- ports of the dental caries studies in the Dental School here. "In these troublesome cases it is first essential to determine the pa- tient's lactobacillus count. The pa- tient is then placed on a diet in which the carbohydrate is moderately re- stricted. This usually involves the omission of all forms of confection, cake, candy, pie, ice cream and other artificially sweetened deserts. After two weeks another count is taken. If there should be no striking change in this diet, it then becomes neces- sary to reduce the amount of starch First on the program will be a com- petition open to the more talented musicians in Ann Arbor. Members of the band and anyone who can play a musical instrument will be eligible to participate. The award for this section will be one semester of free study with any teacher in the School of Music or the financial equivalent. The second portion of the show is to be in a humorous vein, following the lines of an amateur hour, much like last year's. Anyone who can put on some funny antic or skit may tryout, according to Professor Revelli. The applause of the audience will de- cide the winner of this part of the performance, while judges will rule on 'the winner of the musician's con- test. as well as sugar," Dr. Jay explained. Handling Important These cases require intelligent handling by physicians who have a thorough knowledge of dietetics, Dr. Jay pointed out, since very serious disturbances may arise when all car- bohydrate containing foods are re- stricted without regard for the caloric requirements of growing children. Competent dieticians can plan diets, however, that are low in sugar and starch but nutritionally adequate, he said. Justify Ann Arbor's Existence (EDITOR'S NOTE: This is the first nishes the world with a variety of of a series of articles on Ann Arbor's industries prepared by the city staff of products ranging all the way from The Daily) popsicles to heavy duty machinery, By DICK MANN and from midget cameras to baling ma- STAN SWINTON chines, from books to ball bearings. To the student Ann Arbor begins Radios, coil springs, dashboard gad- at the Washtenaw fraternity district gets. telegages, stamping machines and ends just west of Division Street. and home work shop equipment, all Yet entirely aside from the Univer- contribute to industrialuprosperity. sity Ann Arbor fulfills a variety of Not ending here, the' list of products urban functions which would justify goes on to include candy, castings, its existence if it had no student pop- cigars, high-speed steel forgings, fur- ulation. Center of a rich farming niture, lamps and silk lamp shades, area, a steady flow of money comes piston pins, pumps, literature racks, into the downtown shopping district sashes, pharmaceutical and toilet which, on the traditional "going to articles, scientific instruments and town" day of Saturday is thronged apparatus, rugs and screw machine with rural visitors who are drawn parts. from a 15-mile area with a population The assessed valuation of the city i of over 60,000. ' is unusual for a town of 36,000-$37,- But more important than this rural 146,860. Located here are two banks trade to the town is the industrial and one trust company with total de- function which the city serves. Home posits of $19,528,600 and total re- of 23 manufacturing establishments sources of $21,700,000. A building and which employ a total of 2,300 men loan association not included in these and 1,100 women, Ann Arbor fur- figures has assets of $3,000,000. ENSIAN PORT RAIlS I E1- Fur Coats Remodeled I p N W IIE Repaired Cleaned Relined Glazed E. L. Greenbaum 0000 "r 448 Spring Street Dial 9625 r ....,........ .... _,. ..... .. . I j I 4 I V'O I A,. I GE te ".. THE STORY OF A FOOTBALL OPPORTUNIST YALE CAPTAIN ALL-AMERICAN END 1936 ROYAL PORTABLE WITH TOUCH CONTROL Trumble, '38E; and J. F. Wisler, '38E. The Cadet Second Lieutenants named are R. A. Bowman; G. T.l Christiansen; J. J. Earley, '38; G .P. Fuentes; R. E. Fryer, '38; G. W. Ham- mersmith, '38E; K. B. Hook, '38; R. C. House; F. J. Kidder, '38E; J. G. Lambertsen, '38E; V. B. Lindquist; G. T. Peterson, '38E; G. S. Quick, '38; J. J. Skiriski, .'38E; and A. J. Sol- oway, '38E. 13th University Year In Radio OpensMonday "The Michigan University of the Air," under the supervision of Prof. Waldo Abbot, director of broadcast- ing service here, will inaugurate its 13th season, Oct. 18. The University programs, 189 in number, have been designed to stim- ulate interest in all fields studied up- on the campus. Eighty-three members of the fac- ulty have agreed to participate in the broadcasts this season. Dr. Joseph E. Maddy will be i ncharge of 35 music instruction periods, Professor Densmore will bring his class in pronunciation to the air. Kenneth Kelley, Thomas Lawton, John Lehner, James Lovett, Donald McGaw and Colin Weymouth. Zeta Beta Tau: Robert Barnard, Henry Brown, Alan Englander, Oscar Feferman, Warren Friedman, Howard Goldman, Jerome Grossman, Julian Harris, Jerome Mecklenburger, Mil- ton Peterman, Melvin Schlemenson, Finest, most up-to-date portable on the market! Actually ecsier than writing by hand! With Royal's sensational Touch Con- trol, you can instantly adapt the key-tension to your exact finger pressurel Many other exclusive Royal improvements. Costs only few cents a day.