Thursday, May 9, 2013 The Michigan Daily - michigandaily.com Thursday, May 9, 2013 The Michigan Daily - michigandaily.com COSTOLO From Page 1 heart regarding his career after taking an acting class his senior year. It turned out to be more than "saying Arthur Miller lines to each other," so he took another course the next semester and began stand- up comedy. Turning down pro- gramming job offers, he moved to Chicago to try his hand at impro- visational comedy with the Second City, the famous theater company. Costolo offered the picture- perfect version of how life in Chicago could have panned out, then explained the reality. "In the real-world story of what happened, I decided to make a big bet on myself and take the chance to do this because it's what I love," Costolo said. "I was grinding away for a long time and had no money, and we would rehearse during the day and perform these little theaters at night for free and I was taking classes during the day at Second City, as well, trying to learn improvisation and eventually had to get out because I had no money. "So I put my CS degree from Michigan to use wrapping flatware and selling place settings at Crate and Barrel." Improvisation, he said, is less than a skill than an expectation for graduates as they follow their passions. He passed on advice given to him by a director at Second City: "The beauty of improvisation Call: #734-418-4115 Email: dailydisplay@gmail.com e e e L G L L L F RELEASE DATE-Thursday, May9, 2013 Los Angeles Times Daily Crossword Puzzle Edited by Rich Norris and Joyce Nichols Lewis ACROSS 6A lttle fhash ar? 43 Litaepggy 13 Angst-fiald 1 Atkins dietrdo 7 Phsher'starget : 44 Mountaintop genre 8 Medicare section Abbr. homnes 54 Parson's home 13 Freight lineup 8 French meat-and- 45 Unwittingtest 56 Shot contents 14 ianelectronics n v isCdih aet 60langys ke giantl 9aSilvry gray 47 ChareIon k 61 'his Amrican 16 *Classic paradox 10 South American non-members, Life" airer 18 Fjord relative bird named for a often 62 Speed-skating 19 Extended break Greek Tban 48 Shinboes goldmedalist hrornsot. 11 Assoiaed 516sJne 20 Together, on a 12 Many air iies presidential in-law 63 Stop score 14 Half-human 52Some Nintendo 64Blockersfor 21 'Mem Brale se Enterpdse consoles QBs of a 19es Beatles counseoc concert 15Getson ANSWER TO PREVIOUS PUZZLE: 26Aetna's bus. 17 Antediluvian 27Salmon for bagels 21 Wily A M A S K T8 A R SFP F 28 LBJmoseep 22 Placefor a shoe A G A S S I W I R E C I A 29 Residents along 23 Militaryvet I T S I N T H E B A G R A T the Gulf of 24 Name of three S S T S TEA G A U N T Bothnia Ottoman sultans p E C K S B A D B O Y 31 "A nichel ain't 20 Falls spray worth a dime 30rdinalextremes G A S T A N K H E E D anymore" 32"__thata lot O T E R I P O D I B M S speaker 34 Verbending O N L I N E V I D E O C L I P 33Self-effacing 35Antibiotic P O L L TON M T I D A 36 'Comsupwitha t37 alBoEmenNsGO TL NW A S P I N soluton 37" furher0G5A L T I G AEIR 41 Horacemworks reflection... 42Cardgamefor 38 cingbdson S T A Y S X PRAM three fancy cakes 1 0 0 P A P E R T R A I L S 44Somechoristers 39Vegetablealso D N A E Z R AMU N P L U G 46 Down called lady's- E S L D 0 0 M P S A L M S 49 Where agua flows finger xwardedter@aeLcom 86/18/13 4sanny 2013-14 PARKING FOR SALE *Great Locations *Central Campus *Great Rates 734-761-8000 www.primesh.com SUMMER PARKING BEHIND 420 Maynard St. $100/Mo. 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To end his often humorous remarks, Costolo invoked myriad careers University graduates would pursue and had advice no matter where they end up: "Be right there, and nowhere else, in that moment. Soak it all it. And remember to say thank you." In an interview after commencement, Costolo said, "You have this intellectual sense of how big the crowd is, but until you go out there and experience it, you don't really have an appreciation for it." "You have to have a north star," he said of the path - or lack thereof - he endorsed, "but you can't constantly worry about, 'Well, and then I'm supposed to do this,' because life doesn't work that way and you won't experience your life. You'll be living it in service to some expectations that are fiction." LSA graduate Anisha Chadha was the only student speaker on Saturday. Though she came to the University concerned about how she would feel among some 25,000 undergraduates, Chadha said joining student organizations allowed her to create a small, unique community on campus. "I realized, no matter what we were doing, it was almost impossible for me to feel small," Chadha said in her address. "Even when I was in this Big House, with 114,803 other people, I began to realize that what I was feeling was not smallness, but rather I was feeling like I was a part of somethingbigger than myself." Though most use the term "Michigan Difference" to describe the academic and cultural caliber of the University, Chadha explained it as the impact Michigan graduates can have on humanity. "It is the difference we were given the opportunity to make," Chadha said. "It is the knowledge, the empathy and the skills we have gained here that are needed to be able to make a thoughtful difference in the lives of others." As she concluded her speech, Chadha reminded her fellow graduates that they represent the University and the power of its graduates in their future endeavors. "Always remember: you are contributing to our class's 'Michi- gan Difference' and the differ- ence made by all of the Wolverines before us." Parents kicked you out of your house this summer? We'll take you in. Join the summer Daily staff! Contact: kgburke@michigandaily.com [nw-nwM BEHAVIOR From Page 1 Brown said she believes there has been an increase in reports of suspicious behavior due to the release of the safety bulletin in April. She added that people are now offering this information to University Police while it may have been less reported previously. Because the suspects for each of these incidents do not match in description, Brown said rather than a sudden trend of suspicious behavior occurring, the trend lies within the increase of people reportingthe behaviors. In a recent incident, a man - described as white, in his 60s, 5'5" to 57" and with white hair - approached pedestrians on State Street and asked them on dates. While the University Police were unable to locate the suspect, his description does not match that of the suspect from the North Campus incidents. Brown added that upon receiv- ing a report, University Police offi- cers go to the scene to attempt to find a potential suspect. In most cases no actual crime incidents may have occurred and these acts of suspicious behavior do not warrant an ongoing investigation from the University Police. If approached with suspicious behavior, Brown said to imme- diately call the University Police and provide a description of the suspect. Researchers decode molecular message leading to spread of malignant cells By SAM GRINGLAS Daily StaffReporter In a School of Dentistry lab on North University Avenue, researchers have discovered what could eventually change the way doctors treat cancer. In a study published Tuesday in the online journal Nature Communications, Dentistry Prof. Russell Taichman and Research Associate Younghun Jung have deciphered the molecular messages that cause certain cancers to spread. Taichman's lab studies how cancer spreads to bone marrow as well as ways in which stem cells can be used to regenerate bone. The research is significant in the School of Dentistry because bone regeneration is often crucial in dental procedures. Jung, who is involved in research in both areas, decided to join the two sets of experiments rather than perform the studies separately. Both malignant and benign tumors emit distress signals to SMOKING From Page 2 Violating the regulations of the smoke-free initiative is a violation of the Statement of Student Rights and Responsibilities. A student who breaks the rules and is reported by another student or staff member must report to the Office of Student Conflict Resolution. The ban has remained a con- troversial issue since its incep- tion, hailed by some opponents as an infringement on personal free- dom. Among other problems, an opinion article in The Michigan Daily from March said a smoke- free campus that takes away ash- trays for smokers to use leads to 'U' discovery may change way doctors treat cancer recruit healing cells, or very small embryonic-like stem cells. While studying the effect of VSEL stem cells in rehabilitating human bones inserted in mice, Jung decided to include a tumor in the experiment to see how the VSEL cells would interact. In the initial trial, Jung found the tumor contained a huge amount of the healing cells. "I was ecstatic to find that they do, in fact, interact with each other," Jung wrote in an e-mail interview. "As a scientist, I get excited just by coming up with new ideas and theories to test. But when the data seems to support these ideas, it is really something else." After almost three years of research, Taichman and Jung have been able to discover what draws the healing cells to a tumor. While a collaborator at the University of Louisville first identified VSEL cells, Taichman and Jungwere the first to study them in tumors and pinpoint the role the cells play in the spread of cancer. When a tumor develops, the tumor produces a protein that draws the VSEL stem cells inside. Then, the VSEL cells turn into a second type of cell known as cancer associated fibroblasts. Those cells produce a protein that makes cancer cells more aggressive, allowing them to spread to other parts of the body. an increase in littering. That said, there are some designated ash- trays around campus. Another issue commonly reported is uncertainty about the boundaries of the ban. Though Winfield said the ban has been largely successful, there have been a handful of people who take advantage of the relatively lax rules. Rather than turn to law enforcement, Winfield would pre- fer to solve the issue more amica- bly. "Some are angry about the rules, defiant, not aware or don't care and are taking advantage of the fact that we're using light- weight enforcement," he said. "My first preference is to improve signage and advertising." By understanding the ways in which stem cells interact with a tumor and cause cancer to spread, researchers can now study methods through which to block VSEL cells from interact- ing with a tumor. Additionally, high VSEL cell levels in a blood test could potentially serve as a diagnostic meter for detecting cancer earlier. Taichman said it is possible that further research in block- ing VSELs could potentially cre- ate a cure for cancer. Currently, Taichman's lab is attempting to find inhibitors to block the cells as he applies for further fund- ing to continue the research and approval for human trials. Jung said the next steps involve investigating the healing cells' interaction throughout the pro- gression of a cancerous tumor. However, Taichman said many scientists still debate the existence of VSEL stem cells due to their small size and the difficulties associated with identifying them. Taichman said reviewers may also question whether the findings will remain true in other types of cancers. Cancerous prostate tumors are typically used in Taichman's lab because they often spread to other parts of the body, such as bones. The lab has also tested breast cancer tumors. Lena Gray, the smoke-free environment project coordinator for Michigan Healthy Commu- nity, said in a press release that smoking is still an issue on Cen- tral Campus. "We are pursuing other approaches such as adding sig- nage and sidewalk chalk messag- es, to remind everyone that those areas are smoke-free," Gray said. University President Mary Sue Coleman convened a Smoke- Free Advisory Committee at the inception of the ban that meets regularly to address issues such as littering and boundary recog- nition. There are currently 1,159 com- pletely smoke free campuses - including the University - across the U.S. 51 Body shop's reappraisal 55 Spheres 57 Reid or Robbins 58 Deg. for Dilbert creator Scott Adams 59 Deee useful in navigation, or in discovering the hidden Same in the answers to starred clues 65 Honeys 66 Lowly laborer 67 Party animals? 68 Respondsto the MAILER- DAMON DOWN 1 30 Rock' network 2 Cry of wonder 3 One-fifth of DLV 4 WestrAffican capital 5 Sporty [T ] m e per oa oz unezna tmrougn .une 8th. Volunteers wsill join us for meals and cultural outings. Interested persons should contact Lyn Badala- menti at 734-822-3122 or badalamen- til@pittsfield-mi.gov HANDYPERSONNEEDED. Experi- ence preffered but not necessary. 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