Wednesday, My15,1992 -The Mlchgan Daily SummerWeekly-s
'U' uses gene therapy to treat high cholesterol
by Emily Fries
Daily Staff Reporter
Researchers at the University's
Howard Hughes Medical Institute
(HHMI) have successfully begun to
use gene therapy to treat familial
hypercholesterolemia (FH), a lethal
form of high cholesterol.
Patients with FH lack a gene which
is responsible for the production of a
natural cholesterol-lowering protein.
The lethal form of FH affects one in a
A less severe form which leads to
premature heart attacks affects nearly
one in 500 Americans.
The procedure began June 5 with
surgery to remove a small portion of
liver tissue from a patient with FH.
This liver tissue was then geneti-
cally treated and the transformed cells
were re-infused into the patient's liver
three days later.
During those three days, the liver
tissue was broken down into individual
cells and exposed to a harmless virus
that caries the cholesterol-lowering
The virus was permitted to infect
the cells and use the cell's protein-
making system to manufacture the cho-
Now that the cells have been im-
planted into the liver again, it is hoped
that they will grow and continue to
produce the protein.
"We are pleased with how things
are going so far and are particularly
optimistic about the impact of this
therapy on the patient," said James
Wilson, the project's principal investi-
The use of gene therapy to treat
lethal diseases is a relatively new tech-
"Gene therapy has the potential to
significantly alter the way we approach
a number of inherited conditions and
other diseases which involve genetic
changes," said George Zuidema, vice
provost for medical affairs.
He added, "We are excited that the
Medical Center has taken another step
in this new frontier of medicine."
HILL NEAR MAIN, Modern 1 bedroom
$480., A/C, pkng., no pets. 665-4617.
HOUSE FOR RENT-Avail. Aug. 15, 1992.
Near U of M Stadium. Ideal for 2 profes-
sional persons, immaculate, completely
renovated, 2 bdrm., new kit. and bath, new
carpeting, ldry., A/C, 1 1/2 car garage with
opener, private yard. Lease required, no pets,
no smokers, no children. $900/mo.+ all util.
6 Bedroom Furnished Ap.
For Fall * $1600/month
321 E. Liberty, #2
3 Parking Spaces
COPI PROPERTIES " 663-5609
LET'S MAKE A DEAL! 6 bdrm. large
house. Near Rackham. 3 baths and parking,
for Fall, Oakland Mgmt. 761-7491.
LUXURIOUS BI-LEVEL, 2 bdrm.,l 1/2
baths. Available Fall. 1700 Geddes, 741-
OAKLAND NEAR ARCH ST. Furnished 2
bdrm., A/C, Pkng. $760-880. 665-4617.
1 and 2 bedrooms
Call today 663-3098
ONE BEDROOM, NEAR HILL and S.
Main. Large. $510 pins electric. John 769-
M U PROPERTY
Geddes Hill Apartments
Arboretum vicinity; luxurious bi-
level, 2 bdrm 1 1/2 bath, balcony
* Carriage House Apartments
Across from CCRB; luxurious 2
bdrm 1 1/2 bath, only I vacancy
Near Michigan Union; Spacious
contemporary studios & 1 bdrm
* Roommate Finder
# Gradusate Wing
" jacum iWeekends
ONE-BEDROOM APT. Huge 2-person
size, charming older bldg., campus, Fall
lease, pets ok, 662-5819.
PACKARD AT E.U.
HUGE 2 Bdrms. LOADED with Amenities
Only 2 left!
CALL 668-6906 7 days a week!
SHARE A HOME-Large bedroom in beauti-
ful Burns Park home. Street parking nearby,
short-term lease, available September. 663-
STATE AT PACKARD! Unique one-bdrm.
$500 + efficiency $400 - both incl. heat +
water. Unfurnished - above Campus Corner
Party Store. Sept. to Sept. 973-3185
STATE NEAR FULLER: 1 bdrm. in 4
bdrm. furn. house. Non-smoker, no pets,
prefer grads. $300-325, util. inc. 665-4617.
THREE BEDROOM APARTMENTS on
Packard near central campus available for
Fall. Call Wilson White Co. Inc. 995-9200
Available September. 5 bedrooms, Sleeps 7.
Fully Furnished, 2 Baths, Parking, Pets OK.
$1500. CALL NOW, 398-5976.
1 LG. BDRM. in mod. 2 bdrm. apt., free
pkng., ldry., pool, storage, clean, dwshr., next
to Argo park, 5 min. drive to main/N.
campus, walk in closet. A/C, July &/or Aug.
$175 neg. Sue 865-0013
ATTRACTIVE LG. ROOM on Hill St.,
kitchen, ldry., prkg. for male $190 995-3276
FEM. NEEDED TO share 2 bdrm. apt., 15
min. walk to campus. Rent neg. 668-8114.
LARGE DOUBLE in Helen Newberry. If
tnterested, call Dana at 345-5264.
PREGNANT? Professional couple wishes to
adopt a child. Couple has 1 child 4 yrs. old
also adopted & who wishes to have a brother
or sister. Couple can provide a good home
with lots of love. Working with state licensed
agency. Please call us at (313)788-2482 to
get acquainted. Confidentiality will be
SEMEN DONORS NEEDED for a well-es-
tablished infertility clinic. If you are a male
21 - 40 years of age and a graduate student or
aprofessional 5'9" or salter we need you.
Donors will be paid $55 per acceptable
specimen. For further info. please write P.O.
Box 2674, Ann Arbor, MI 48106
Sell it.. .find it!
. Confidential, and Re putable
. We GUARANTEE you a match
. Single UM professors and
students among our members
. Introductory Offer: $96/yr
. FREE Brochure: 484-5650
Resumes, reports, thesislaser 426-5217
NEED MONEY FOR SCHOOL??
College Tuition Consultants can help.
Call Paula 437-7738 for free info.
ATTENTION: Excellent income for home
assembly work. 504-656-1700. DEPT. 2720
DAYCARE:Doctoral students need assis-
tance for adorable 8 mo. old twin girls start-
ing in Aug. Flexible Hrs. Though 9-3 T, W,
Th, is preferred. Near Washtenaw & Huron
Pkwy. $5.00/hr. Please provide references.
EXPERIENCED BABYSITTER WAN.
TED for 3 yr. old & newborn. 6-10 hrs./wk.
Own transportation. To start avg. through
school year. Call 663-1448.
HOUSECLEANER 6-7 hrs./wk. Must have
a car. $7/hr. Call 769-1355.
LOOKING FOR SUMMER
EMPLOYMENT? Call AATEC Tem-
MOTHER'S HELPER- Reliable n-smkr.
who loves kids & is neat & organized to care
for our 18 mo. old daughter in our home 15-
20 or more bin. per wk., must have exp.,
good ref. & own car. Avail. sum. & through
next yr. 663-3223 before 6pm
PART-TIME WORKERS needed Monday
- Friday, 5-9pm, $5/hr. to start. 769-1975.
SUBJECTS NEEDED for psych. reaction
time experiments. Right-handed, male, native
English speaker, normal vision and hearing.
Hourly pay. Call 936-2056.
POSTDOCTORAL POSITIONS in
Transplantation Immunology. Departments
of Pathology, Medicine, and Surgery.
University of Michigan. Beginning after
August 1, 1992. An appropriate candidate
will have a background in immunology and
molecular biology, and interests in allograft
tolerance and gene transfer. Contact: Theresa,
1520 MSRB I, Box 0666. Phone 747-2777
for further information.
WANTED-Custodial help the week of art
fair, July 21-26. The jobs will consist of
maintaining the public areas inside the buil-
ding and keeping the outside area clean.
Flexible schedule; $5.25/hr. Apply at the
Union in Room 1310.
WARM, CARING, RESPONSIBLE adult
to care for our 6 mo. infant bay in oar old
westside home. M-W-F, 1-5 pm. Starting in
Sept. References desired. 665-1736.
The Michigan Daily
2-3 hours per day between
12 noon and 4 p.m.
Begin September 8-be part of the
Daily operation to help produce dis-
play ads, do pasteup for the classified
pages, andotherproductionduties. Ex-
perience in graphics, ad layout, type-
setting, and pasteup desirable. Must
know Macintosh, be familiar with
PageMaker software, and have a
sincere interest in learning newspaper
Reliability an absolute must!
U-M students only apply by August I to:
Mary Jo Gord
SUCCEED IN RECRUITING
Study challenging questions on cassette.
Suggested answers included. Convenient.
Send $15 to Search Request, 1343 Fox Run,
Ste. 208, Willoughby, OH 44094.
TICKET FOR SALE--Round trip from
Newark to Detroit. July 24th to 26th.
$150.00. Call 747-9588
VACATION LAKE FENTON 2 bdrm.
cbalet. 45 min. no. Beautiful view (313) 750-
CHEAP! Plane ticket (from Detroit to
Newark, NJ for late August) for sale. Call:
ITHACA-- Round triptkit. on USAir. Call for
details. Best offer over $100. Gary 741-8182.
AIRLINE TKT:Roundtrip anywhere Con-
tinental fliesin USA. Must use by 8/31/92.
$149-199. John 994-0634 eves.
Heading fur EUROPE this summer? Jet
there anytime for $169 from the East Coast,
$229 from the Midwest (when available)
with AIRHITCH(r)l (Repored in iets Got
& NY Times.) AIRHITCH(r) 212-864-2000.
1 FEMA LE Non-smoking roommate wanted
to share one room of a two bdrm. apt. on
Church Si. 930-0575 after 5 p.m.
FEMALE GRAD STUDENTS seekin
roommates. Lg. 4 bdrm. house. Feature
Parkedl Call for an appeintmeni 7 days a
week. 668-6906, Modern Management.
ROOMMATE FINDER so share luxurios
2 bdrm., 1 8 bath apt., 741-9300.
ROOMMATE NEEDED for Fatl:6 berm.
hue., new appls., 2 kiu.,farn.i-313-363-2536
SEEKING LESBIAN, gay and gay-friendly
people to house-hunt together to economize
on rent. Pets cool, drugs asi coot. Call Andy,
YOUNG, FUN, YET PROFESSIONAL
FEMALE seeks roommute for 2 berm. 2
bt.apt. AvaiL. now. Call Lamra ai 429-
IBM PS-2 VGA $1299.
NECMultispeed. sapop, backlit, $600.
Tshiba laptop , $499.
" ''. . . . . .. . . . . . . . .. . . . . . . . _ ." *.. .. _ ... ...."
-read them Daily