The Michigan Daily - michigandaily.com
From page 1
lines registered with the National
Institutes of Health, many were
later found to be either incapable
of growth or contaminated with
animal proteins. Today only 16 are
uncontaminated and viable for
research and treatment.
Although these lines may be
used to generate healthytissue for
patients who have lost cells because
of disease, they are far from suit-
able for the type of research Mor-
rison is interested in.
The creation of the room in the
Life Sciences Building was sup-
posed to solve that problem.
Now, though, before research-
ers can scour the world for suitable
lines, they must complete several
stages of approval at the University
In order for University research-
ers to obtain non-federally-
approved lines, a Material Transfer
Agreement must first be processed
and documented by the Universi-
ty's Division of Research Develop-
ment and Administration, said Judy
Nowack, the University's associate
vice president for research. The
division assists researchers with
Tom Zdeba, who reviews the
agreements, said they are used to
monitor and track materials like
stem cells and software individu-
But before a human embryonic
stem cell transfer can be negoti-
ated, the University's Embryonic
Stem Cell Research Oversight Com-
mittee must approve it.
Morrison said the committee
was only established last week.
Zdeba, who works in the Divi-
sion of Research, said this step
allows members of the University
community to monitor, track and
* make ethical decisions concerning
stem cell technology.
Morrison said he supports this
oversight and is a member of the
committee himself - though he
said he would recuse himself from
approval process in issues concern-
ing his own work.
He said he does not expect there
to be any applications involving
ethically problematic work.
FINDING THE LINES
Even when researchers receive
the necessary approval, the specific
stem cell line needed for a project
might not even exist.
The ability to derive new lines
gives other schools in other states
an advantage over the University,
at which state laws prevent the
creation of new lines, Morrison
from destruction, it only prevents
Michigan scientists from conduct-
ing medical research that is being
done by scientists throughout most
of the rest of the country," Mor-
rison said in an e-mail interview.
"We've been leaders at the U of M
in all research, and this legislation
prevents us from doing many things
with stem cells that we would like
For example, Morrison said he
plans to use the privately funded
lab to research heritable diseases
like Huntington's disease that
result in the degradation of brain
In most cases, ifa parent carries
the Huntington's gene, the child
will have a 50 percent chance of
developing the disease. The high
rate of heritability for Hunting-
ton's disease, as well as its status as
incurable and untreatable makes it
attractive to researchers.
In order to study the disease,
Morrison would need. stem cells
affected with Huntington's dis-
ease, which are not included in the
In this case, a good source for
affected lines would be unused
embryos from fertility clinics, Mor-
John Randolph, head of the
Reproductive Endocrinology and
Infertility Division at the Universi-
ty, said that although many couples
seek the help of fertility clinics to
achieve pregnancy, increased suc-
cess of medical procedures such as
in vitro fertilization has resulted in
an abundance of embryos that will
not be used.
"We have a lot of embryos in
storage that have been here for a
longtime," he said.
After three years, the embryos
become property of the clinic and
will likely never be implanted in a
womb and carried to term.
"I wish we had a better solution
for what to do with the embryos,
but we don't," Randolph said.
Morrison said he would only
need one stem cell line from an
embryo affected by Huntington's
disease to begin his research.
that could lead to breakthroughs
that in the future might obviate
the need for parents to discard
these Huntington embryos," Mor-
rison wrote. "This is a fundamental
principle of clinical trials in which
we often perform experiments
on patients that we know that we
cannot save in order to learn new
things that could help us to save
Morrison said that by observing
the stem cells affected with neu-
rodegenerative diseases grow in a
Petri dish he gain a better under-
standing of the diseases to apply
toward different treatments that
would slow or halt the destruction
of brain cells caused by such dis-
Morrison may not be able to
start quite yet, but he is rehears-
ing for this research by practicing
handling NIH-approved lines. He
started experiments deriving neu-
ral stem cells and coaxing them to
give rise to cells in the peripheral
Morrison continueseto prepare his
privately funded lab in anticipation of
newly derived embryonic stem cells
that will help him in his pursuit.
Until then, the lab remains
From page 1
to start over after about a year of
For instance, the driver now has
to sit upright.
"It adds a tremendous amount
of drag to have (the driver) sitting
cross-legged," Ignaut said.
The solar array surface area
specification was also greatly
diminished, forcing designers to
strive for efficiency even more than
they had in the past.
Because the cars compete on
public roads, race officials at
the world competition have also
recently imposed speed limits and
large time penalties for going over
"They're trying to make it more
real-world," Ignaut said. "Like add-
ingan actual steeringwheel instead
of handles and having the driver
Real-world applicability is a key
part of the solar car project. For
example, the communications sys-
tem provided by Motorola is mili-
Every component was designed
for efficiency, low weight and safe-
ty. There were many aspects of the
2007 car that Ignaut wouldn't even
talk about. He feared that other
teams would gain an advantage if
they knew what Michigan had in
The team members seem opti-
mistic about their chances to win
the World Solar Challenge in the
Australian Outback, the sport's
To qualify for the biannual race,
judges study and test the car's abil-
ity to function. In the team's last
appearance - the 2005 race - they
On the wayto the auto show from
Ann Arbor on Friday, team mem-
bers enthusiastically discussed the
merits of affixing spinner rims to
the solar car, and how they might
During each race, an entourage,
composed of team members, rides
along with the car. There are scout,
lead, chase, communications, mete-
orology and camera vehicles.
Teams scout ahead to time traf-
fic lights, construction, cross-
winds and weather. A laundry list
of calculations enable maximum
optimization, but any slight hitch
throws calculations out the door
and sparks a scramble of activity to
find the new optimal cruise speed.
"Without the strategy side, it could
never work," Ignaut said.
As with any large-scale project,
the Solar Car Team constantly
faces staggering setbacks and
problems. Ignaut described a situ-
Tuesday, January 23, 2007 - 7
ation in 2001 when the team was
doing practice runs just under
three weeks before a race. The car
crashed while traveling at more
than 60 miles per hour. The team
had to rebuild.
"Fortunately, the driver walked
away from that one," Ignaut said.
To ensure that the team's next
journey to the Australian Outback
for the World Solar Challenge goes
smoothly, logistics team member
Brooke Bailey helps plan every step
of the way, down to what the team
members will eat and where they
The car has to be shipped on a
Boeing 747 and inspected by cus-
toms, while the support vehicles
are shipped by sea. All the spare
parts must arrive on time and on
location, and strategy has to be
coordinated. According to the
team's information packet, logis-
tics alone take up over a quarter of
All told, the solar car project
brings together more than 100
students, hundreds of thousands
of sponsorship dollars and care-
ful effort to produce results on
the 3,000 kilometer race across
the Outback. Working on the car,
described by many as a "remark-
able experience," provides a start-
ing point for the careers of many
young University students.
Clinton expects to raise $100m in 2007
Senator says she will
not accept public
financing in 2008 bid
ALBANY, N.Y. (AP) - White
House hopeful Sen. Hillary Rod-
ham Clinton will not accept public
campaign financing for either the
Democratic primaries or, if she
wins the nomination, the general
Clinton's decision had been
widely expected given her and her
husband's proven ability to raise
vast sums of money quickly. Her
advisers have not disputed esti-
mates that she will raise $100 mil-
lion or more before the year is out.
The New York senator already has
more than $14 million in the bank,
money left from her successful re-
can be spentuon her presidential bid.
While both President Bush
and Democratic challenger John
Kerry rejected public funding for
their primary campaigns in 2004,
they did accept $74.5 million each
for the general election campaign.
The funding for the general elec-
tion was expected to reach $85
million for the major party candi-
dates in 2008.
Analysts had been predicting
that the major candidates for 2008
would reject the public financing
option for both primaries and the
general election because of the
growing cost of competing.
the michigan daily
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lake advantage of unexpected oppor-
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Birthdatekof: Mariska Hargitay,
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OLD WEST SIDE -
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