The Michigan Daily - michigandaily.com
LAB
From page 1
lines registered with the National
Institutes of Health, many were
later found to be either incapable
of growth or contaminated with
animal proteins. Today only 16 are
uncontaminated and viable for
research and treatment.
Although these lines may be
used to generate healthytissue for
patients who have lost cells because
of disease, they are far from suit-
able for the type of research Mor-
rison is interested in.
The creation of the room in the
Life Sciences Building was sup-
posed to solve that problem.
Now, though, before research-
ers can scour the world for suitable
lines, they must complete several
stages of approval at the University
level.
In order for University research-
ers to obtain non-federally-
approved lines, a Material Transfer
Agreement must first be processed
and documented by the Universi-
ty's Division of Research Develop-
ment and Administration, said Judy
Nowack, the University's associate
vice president for research. The
division assists researchers with
external funding.
Tom Zdeba, who reviews the
agreements, said they are used to
monitor and track materials like
stem cells and software individu-
ally.
But before a human embryonic
stem cell transfer can be negoti-
ated, the University's Embryonic
Stem Cell Research Oversight Com-
mittee must approve it.
Morrison said the committee
was only established last week.
Zdeba, who works in the Divi-
sion of Research, said this step
allows members of the University
community to monitor, track and
* make ethical decisions concerning
stem cell technology.
Morrison said he supports this
oversight and is a member of the
committee himself - though he
said he would recuse himself from
approval process in issues concern-
ing his own work.
He said he does not expect there
to be any applications involving
ethically problematic work.
FINDING THE LINES
Even when researchers receive
the necessary approval, the specific
stem cell line needed for a project
might not even exist.
The ability to derive new lines
gives other schools in other states
an advantage over the University,
at which state laws prevent the
creation of new lines, Morrison
said.
"Thelawdoesn'tprotectembryos
from destruction, it only prevents
Michigan scientists from conduct-
ing medical research that is being
done by scientists throughout most
of the rest of the country," Mor-
rison said in an e-mail interview.
"We've been leaders at the U of M
in all research, and this legislation
prevents us from doing many things
with stem cells that we would like
to do."
For example, Morrison said he
plans to use the privately funded
lab to research heritable diseases
like Huntington's disease that
result in the degradation of brain
cells.
In most cases, ifa parent carries
the Huntington's gene, the child
will have a 50 percent chance of
developing the disease. The high
rate of heritability for Hunting-
ton's disease, as well as its status as
incurable and untreatable makes it
attractive to researchers.
In order to study the disease,
Morrison would need. stem cells
affected with Huntington's dis-
ease, which are not included in the
approved lines.
In this case, a good source for
affected lines would be unused
embryos from fertility clinics, Mor-
rison said.
John Randolph, head of the
Reproductive Endocrinology and
Infertility Division at the Universi-
ty, said that although many couples
seek the help of fertility clinics to
achieve pregnancy, increased suc-
cess of medical procedures such as
in vitro fertilization has resulted in
an abundance of embryos that will
not be used.
"We have a lot of embryos in
storage that have been here for a
longtime," he said.
After three years, the embryos
become property of the clinic and
will likely never be implanted in a
womb and carried to term.
"I wish we had a better solution
for what to do with the embryos,
but we don't," Randolph said.
Morrison said he would only
need one stem cell line from an
embryo affected by Huntington's
disease to begin his research.
"Itisdesperatelyneededresearch
that could lead to breakthroughs
that in the future might obviate
the need for parents to discard
these Huntington embryos," Mor-
rison wrote. "This is a fundamental
principle of clinical trials in which
we often perform experiments
on patients that we know that we
cannot save in order to learn new
things that could help us to save
future patients."
Morrison said that by observing
the stem cells affected with neu-
rodegenerative diseases grow in a
Petri dish he gain a better under-
standing of the diseases to apply
toward different treatments that
would slow or halt the destruction
of brain cells caused by such dis-
eases.
Morrison may not be able to
start quite yet, but he is rehears-
ing for this research by practicing
handling NIH-approved lines. He
started experiments deriving neu-
ral stem cells and coaxing them to
give rise to cells in the peripheral
nervous system.
Morrison continueseto prepare his
privately funded lab in anticipation of
newly derived embryonic stem cells
that will help him in his pursuit.
Until then, the lab remains
unused.
SOLAR CAR
From page 1
to start over after about a year of
work.
For instance, the driver now has
to sit upright.
"It adds a tremendous amount
of drag to have (the driver) sitting
cross-legged," Ignaut said.
The solar array surface area
specification was also greatly
diminished, forcing designers to
strive for efficiency even more than
they had in the past.
Because the cars compete on
public roads, race officials at
the world competition have also
recently imposed speed limits and
large time penalties for going over
the limit.
"They're trying to make it more
real-world," Ignaut said. "Like add-
ingan actual steeringwheel instead
of handles and having the driver
sitting up."
Real-world applicability is a key
part of the solar car project. For
example, the communications sys-
tem provided by Motorola is mili-
tary grade.
Every component was designed
for efficiency, low weight and safe-
ty. There were many aspects of the
2007 car that Ignaut wouldn't even
talk about. He feared that other
teams would gain an advantage if
they knew what Michigan had in
the works.
The team members seem opti-
mistic about their chances to win
the World Solar Challenge in the
Australian Outback, the sport's
premier race.
To qualify for the biannual race,
judges study and test the car's abil-
ity to function. In the team's last
appearance - the 2005 race - they
took third.
On the wayto the auto show from
Ann Arbor on Friday, team mem-
bers enthusiastically discussed the
merits of affixing spinner rims to
the solar car, and how they might
affect efficiency.
During each race, an entourage,
composed of team members, rides
along with the car. There are scout,
lead, chase, communications, mete-
orology and camera vehicles.
Teams scout ahead to time traf-
fic lights, construction, cross-
winds and weather. A laundry list
of calculations enable maximum
optimization, but any slight hitch
throws calculations out the door
and sparks a scramble of activity to
find the new optimal cruise speed.
"Without the strategy side, it could
never work," Ignaut said.
As with any large-scale project,
the Solar Car Team constantly
faces staggering setbacks and
problems. Ignaut described a situ-
Tuesday, January 23, 2007 - 7
ation in 2001 when the team was
doing practice runs just under
three weeks before a race. The car
crashed while traveling at more
than 60 miles per hour. The team
had to rebuild.
"Fortunately, the driver walked
away from that one," Ignaut said.
To ensure that the team's next
journey to the Australian Outback
for the World Solar Challenge goes
smoothly, logistics team member
Brooke Bailey helps plan every step
of the way, down to what the team
members will eat and where they
will sleep.
The car has to be shipped on a
Boeing 747 and inspected by cus-
toms, while the support vehicles
are shipped by sea. All the spare
parts must arrive on time and on
location, and strategy has to be
coordinated. According to the
team's information packet, logis-
tics alone take up over a quarter of
its budget.
All told, the solar car project
brings together more than 100
students, hundreds of thousands
of sponsorship dollars and care-
ful effort to produce results on
the 3,000 kilometer race across
the Outback. Working on the car,
described by many as a "remark-
able experience," provides a start-
ing point for the careers of many
young University students.
Clinton expects to raise $100m in 2007
Senator says she will
not accept public
financing in 2008 bid
ALBANY, N.Y. (AP) - White
House hopeful Sen. Hillary Rod-
ham Clinton will not accept public
campaign financing for either the
Democratic primaries or, if she
wins the nomination, the general
election campaign.
Clinton's decision had been
widely expected given her and her
husband's proven ability to raise
vast sums of money quickly. Her
advisers have not disputed esti-
mates that she will raise $100 mil-
lion or more before the year is out.
The New York senator already has
more than $14 million in the bank,
money left from her successful re-
electioncampaignlastyear.Thefunds
can be spentuon her presidential bid.
While both President Bush
and Democratic challenger John
Kerry rejected public funding for
their primary campaigns in 2004,
they did accept $74.5 million each
for the general election campaign.
The funding for the general elec-
tion was expected to reach $85
million for the major party candi-
dates in 2008.
Analysts had been predicting
that the major candidates for 2008
would reject the public financing
option for both primaries and the
general election because of the
growing cost of competing.
the michigan daily
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For tuesday, Jan. 23, 2007
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(March 21 to April 19)
lake advantage of unexpected oppor-
tunities to travel, take a course or get fur-
ther education in some way. You have a
chance to expand your experience of the
world now.
TAURUS
(April 20 to May 20)
Unexpected inheritances, favors, gifts
and goodies come your way now. Don't
question anything. Don't worry about
attached strings. Just say thank you.
GEMINI
(May 21to June 20)
Partnerships can expand your world in
a wonderful way now. Others might
have seen this coming; nevertheless, you
seem to be the last to know! Go figure.
CANCER
(June 21to July 22)
Surprise job opportunities can land in
your lap now. Act quickly, because this
window of opportunity will be brief. You
deserve this.
LEO
(July 23 to Aug. 22)
Romance, love affairs, unexpected
vacations, new turns and twists with
sports and pleasant tines with children
are just some of the things that catch you
off-guard in a lovely way now. Enjoy
your good fortune.
VIRGO
(Aug. 23 to Sept. 22)
Many of you have a lovely chance to
expand your home or your family, or
both. Something is definitely enriching
your personal life. This is excellent.
LIBRA
(Sept. 23 to Oct. 22)
Good news, perhaps related to rela-
tives and siblings, comes your way now.
Whaeser ocurs will lift your spirits and
make you htappier.
SCORPIO
(Oct. 23 to Nov. 21)
Be on the lookout for unexpected
ways to boost your earnings. They are
definitely there waiting in the wings.
However, you're going to have to act
quickly.
SAGITTARIUS
(Nov. 22 to Dec. 21)
Good fortune is smiling on you now.
Surprise favors and goodies can come to
you out of the blue. Some of these will
be in the form of an opportunity that you
must quickly grab.
CAPRICORN
(Dec. 22 to Jan. 19)
A minor epipbany might occur to you
now. Something happens that really
opens your eyes and makes you appreci-
ate who you are and what you have.
AQUARIUS
(Jan. 20to Feb. 18)
Friends and groups seek you out now.
Someone wants to be your friend. Clubs
and groups want to call you one of their
own. Consider this a compliment.
PISCES
(Feb. 19to March 20)
Surprise career opportunities can defi-
nitely come your way now. Be receptive
to this. And be ready to act. This window
of opportunity is very brief - but it's
there!
YOU BORN TODAY There's some-
thing about you that is distinctive and
somehow very exclusive to your charac-
ter. You have your own style. Because of
this, you make a lasting impression on
others. Many of-you have specific tech-
nical skills. You have high ideals, and
you invariably choose the honorable
path. Expect a fun-loving social year
ahead that especially promotes partner-
ships of all kinds.
Birthdatekof: Mariska Hargitay,
actress; Brendan Shanahan, hockey
player; Humphrey Bogart, actor.
('2007 King Features Syndicate, ,In.
OLD WEST SIDE -
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Varsity Management
(734) 668.1100.
I