S a l e s M a n a g e m e n t P r o g r a m s t a r t i n g J a n u a r y , 2 0 1 8 Enrollment Starts November 1 st The researchers validated their findings with human samples at the Sheba Medical Center, Tel Hashomer in Ramat Gan and then with a bigger cohort of samples at the University of Maryland. An RNA profiling and analysis of samples taken from pancreatic cancer patients showed the same genomic pattern found earlier in mouse and human models of pancreatic can- cer. “This gave us a clear picture of targets for therapy development,” Satchi-Fainaro said. “The idea is to try to ‘re-educate’ the pancre- atic cells so as to inhibit the PLK1 gene and bring out, help express, the miR-34a gene,” with the aim of delaying development of the disease and prolonging the life of patients. Sales U Sales Management Training for Professionals U 29200 Northwestern Hwy, Suite #115 Southfi eld, MI 248-726-1090 info@armstrongsalescoaching.com WWW.ARMSTRONGSALESCOACHING.COM Change the Way the World Views You With a Wonderful New Smile! Let Drs. Nemeth and Katranji restore your smile for a younger, more youthful appearance with the help of minimally invasive treatment for gum recession (the remarkable Pinhole Technique), gum disease treatment (LANAP Laser Therapy), and Dental Implants for missing or diseased teeth. JONATHAN BLOOM CREATING A ‘TAXI’ In a second stage of the research, the scientists devised a new nanoparticle that can selectively deliver genetic material to a tumor without side effects for the sur- rounding healthy tissues. “We designed the nanocarrier to deliver two passengers: the miR-34a and a small interfering RNA (siRNA) that silences the PLK1,” Satchi- Fainaro said. “The smart nanopar- ticle knows how to find the pan- creatic cancer and release its cargo that will silence the PLK1 and help express the miR-34a. “The nanoparticle is like a taxi carrying two important passengers,” she explained. “Many oncology pro- tocols are cocktails, but the drugs usually do not reach the tumor at the same time. But our ‘taxi’ kept the ‘passengers’ — and the rest of the body — safe the whole way, targeting only the tumor tissue. Once it ‘parked,’ an enzyme pres- ent in pancreatic cancer caused the carrier to biodegrade, allowing the therapeutic cargo to be released at the correct address — the tumor cells.” To validate their findings, the sci- entists injected the new nanoparti- cles into pancreatic tumor-bearing mice and observed that by re-bal- ancing these two targets — increas- ing the expression of one and blocking that of the other — they significantly prolonged the survival of the mice. “We managed to change the genetic signature of pancreatic can- cer cells and inhibit the cancer gene and increase the survival of mice,” she said. “Hopefully, this will lead to the development of new drugs that will increase the overall survival of cancer patients.” • Joseph R. Nemeth DDS Amar Katranji DDS, MS Joseph R. Nemeth DDS is a world-class periodontist who has remained committed to providing exceptional care for over 25 years for patients in the Metro Detroit Area. Amar Katranji DDS, MS is a periodontist specializing in dental implant placement, advanced bone grafting and immediate fi xed dentures. He is highly skilled in handling complex implant situations and has earned a reputation of being one of the area’s foremost experts on such cases. As one of the area’s foremost experts in periodontics, Dr. Nemeth has played a major role in applying innovative technological advances to current periodontal practice. He is recognized by his peers as being a leader in periodontics. Dr. Nemeth is the recipient of several top awards and rare dental certifi cations. He has achieved a number of notable accomplishments including being the fi rst periodontist in the United States to use a dental laser and more recently, the fi rst periodontist in Michigan to be personally trained and certifi ed by Dr. John Chao to offer the Pinhole Gum Rejuvenation Technique. Dr. Nemeth is a Master in the College of Sedation in Dentistry and offers sedation to his surgical patients to eliminate any discomfort or fear. Dr. Katranji is dedicated to both research and to practice. He is well published in prestigious professional journals and lectures internationally on periodontal and implant-related topics. He uses advanced technology and progressive surgical techniques to help his patients achieve the best dental health possible. BEFORE AFTER BEFORE AFTER ESTHETIC PROCEDURES Pinhole Gum Rejuvenation for tooth recession LANAP Laser Therapy for gum disease | Dental Implants Cosmetic Gum Recontouring | Periodontal Plastic Surgery Call 248-357-3100 for an appointment to begin your journey to your wonderful new smile. Prof. Ronit Satchi-Fainaro, chair of the Department of Physiology and Pharmacology at TAU’s Sackler Faculty of Medicine 29829 Telegraph Road, Suite 111 Southfi eld, Michigan 48034 248.357.3100 | www.drnemeth.com jn January 25 • 2018 81