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The researchers validated their
findings with human samples at
the Sheba Medical Center, Tel
Hashomer in Ramat Gan and then
with a bigger cohort of samples at
the University of Maryland. An RNA
profiling and analysis of samples
taken from pancreatic cancer
patients showed the same genomic
pattern found earlier in mouse and
human models of pancreatic can-
cer.
“This gave us a clear picture of
targets for therapy development,”
Satchi-Fainaro said. “The idea is
to try to ‘re-educate’ the pancre-
atic cells so as to inhibit the PLK1
gene and bring out, help express,
the miR-34a gene,” with the aim of
delaying development of the disease
and prolonging the life of patients.
Sales
U
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Training for Professionals
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Southfi eld, MI
248-726-1090
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Change the Way the World Views You
With a Wonderful New Smile!
Let Drs. Nemeth and Katranji restore your smile for a younger, more youthful appearance with the
help of minimally invasive treatment for gum recession (the remarkable Pinhole Technique), gum
disease treatment (LANAP Laser Therapy), and Dental Implants for missing or diseased teeth.
JONATHAN BLOOM
CREATING A ‘TAXI’
In a second stage of the research,
the scientists devised a new
nanoparticle that can selectively
deliver genetic material to a tumor
without side effects for the sur-
rounding healthy tissues.
“We designed the nanocarrier to
deliver two passengers: the miR-34a
and a small interfering RNA (siRNA)
that silences the PLK1,” Satchi-
Fainaro said. “The smart nanopar-
ticle knows how to find the pan-
creatic cancer and release its cargo
that will silence the PLK1 and help
express the miR-34a.
“The nanoparticle is like a taxi
carrying two important passengers,”
she explained. “Many oncology pro-
tocols are cocktails, but the drugs
usually do not reach the tumor at
the same time. But our ‘taxi’ kept
the ‘passengers’ — and the rest of
the body — safe the whole way,
targeting only the tumor tissue.
Once it ‘parked,’ an enzyme pres-
ent in pancreatic cancer caused the
carrier to biodegrade, allowing the
therapeutic cargo to be released at
the correct address — the tumor
cells.”
To validate their findings, the sci-
entists injected the new nanoparti-
cles into pancreatic tumor-bearing
mice and observed that by re-bal-
ancing these two targets — increas-
ing the expression of one and
blocking that of the other — they
significantly prolonged the survival
of the mice.
“We managed to change the
genetic signature of pancreatic can-
cer cells and inhibit the cancer gene
and increase the survival of mice,”
she said. “Hopefully, this will lead to
the development of new drugs that
will increase the overall survival of
cancer patients.” •
Joseph R. Nemeth DDS
Amar Katranji DDS, MS
Joseph R. Nemeth DDS is a world-class periodontist who has
remained committed to providing exceptional care for over 25 years
for patients in the Metro Detroit Area.
Amar Katranji DDS, MS is a periodontist specializing in dental implant
placement, advanced bone grafting and immediate fi xed dentures.
He is highly skilled in handling complex implant situations and has
earned a reputation of being one of the area’s foremost experts on
such cases.
As one of the area’s foremost experts in periodontics, Dr. Nemeth has
played a major role in applying innovative technological advances to
current periodontal practice. He is recognized by his peers as being
a leader in periodontics.
Dr. Nemeth is the recipient of several top awards and rare dental
certifi cations. He has achieved a number of notable accomplishments
including being the fi rst periodontist in the United States to use a
dental laser and more recently, the fi rst periodontist in Michigan to
be personally trained and certifi ed by Dr. John Chao to offer the
Pinhole Gum Rejuvenation Technique.
Dr. Nemeth is a Master in the College of Sedation in Dentistry and offers
sedation to his surgical patients to eliminate any discomfort or fear.
Dr. Katranji is dedicated to both research and to practice. He is
well published in prestigious professional journals and lectures
internationally on periodontal and implant-related topics. He uses
advanced technology and progressive surgical techniques to help
his patients achieve the best dental health possible.
BEFORE
AFTER
BEFORE
AFTER
ESTHETIC PROCEDURES
Pinhole Gum Rejuvenation for tooth recession
LANAP Laser Therapy for gum disease | Dental Implants
Cosmetic Gum Recontouring | Periodontal Plastic Surgery
Call 248-357-3100 for an appointment
to begin your journey to your wonderful new smile.
Prof. Ronit Satchi-Fainaro, chair of the Department of Physiology and Pharmacology at
TAU’s Sackler Faculty of Medicine
29829 Telegraph Road, Suite 111
Southfi eld, Michigan 48034
248.357.3100 | www.drnemeth.com
jn
January 25 • 2018
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