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December 25, 2008 - Image 44

Resource type:
Text
Publication:
The Detroit Jewish News, 2008-12-25

Disclaimer: Computer generated plain text may have errors. Read more about this.

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who have kidney failure.

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December 25 • 2008

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"HIV positivity is still
considered an absolute
contraindication to renal
transplantation in most
transplant centers:' Dr.
Gruber said. "This stems
from the fear that further
immunosuppressing these
patients with pharma-
cologic agents, over and
above their baseline state
Dr. Gruber follows up with an HIV-positive patient
of immunosuppression
who had a kidney transplant six years ago.
from the disease itself,
would produce an unac-
Wayne State University
ceptably high risk of infections and
School of Medicine trans-
malignancy.
plant team in Detroit is
"However, this has not proven to be
offering new hope to HIV-positive
the case in patients who are maintained
patients suffering kidney failure.
on HAART therapy with adequate cell
A team led by Scott A. Gruber, M.D., counts and suppression of the virus.
performed the first two renal kidney
"HIV-positive patients are no longer
transplants in HIV-positive patients in dying rapidly from AIDS, can have
Michigan. He and his team at Harper
prolonged survival and may even
University Hospital have gone on to
develop renal failure over the long
perform an additional seven kidney
term on the basis of their HIV infec-
transplants for patients with HIV, with tion;' he added.
vastly lowered incidence of infection
"There is no longer any reason to
and rejection.
deny the appropriate HIV-positive
Dr. Gruber's protocol and find-
candidate a chance at receiving a kid-
ings were published in July in
ney transplant!"
Transplantation, one of two major
Many transplant centers, he noted,
journals in the field of trans-
harbor concerns regarding the close
plant surgery. The publication in
monitoring HIV-positive patients
Transplantation centers on Dr. Gruber's require due to powerful drug interac-
results with the first eight patients.
tions between the HAART medications
Only two other transplant centers in and the immunosuppressive agents
the U.S. — Drexel University and the
required to reduce the chance of trans-
University of California, San Francisco plant rejection. "We are very fortunate
— have reported results on a larger
here at Wayne State to have assembled
number of such cases, said Dr. Gruber, a team of experts to help care for these
professor and chief of the Section
most challenging patients, with active
of Transplant Surgery for the Wayne
participation from transplant surgery,
State University School of Medicine,
nephrology, infectious disease and
and director of the Organ Transplant
pharmacy," he said.
Program at Harper University
While HIV-positive patients previ-
Hospital. He lives in Southfield.
ously were not considered viable for
The patients who received the trans- kidney transplantation, when suffer-
planted kidneys were required to have ing organ failure — either from the
had CD4 counts above 200 cells/mm3
disease or other causes — they were
and an ultrasensitive viral load for
maintained on dialysis.
HIV below 50 copies/ml for at least six
"However, just like HIV-negative
months while receiving highly active
patients, the quality of life on dialysis
antiretroviral therapy (HAART).
is poorer and the results of renal trans-

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