Health & Fitness ON THE COVER A Matter Of Life Jews rally to expand embryonic stem cell research. George Cantor Special to the Jewish News Ann Arbor 0 ne refrigeration unit after anoth- er lines the corridor outside the neurology research lab at the University of Michigan Medical School. "I have more refrigerators than shoes," says Dr. Eva Feldman, who heads the research group and is also director of the university's A. Alfred Taubman Medical Research Institute. The lab covers 3,750 square feet in the neurology building, across the street from University of Michigan Hospital. The refrigeration units are filled with samples of DNA, its close genetic relative RNA, animal tissue and human tissue. Some of the most advanced research in the field . is going on here — with one significant exception. Embryonic stem cell lines are in sharply limited supply. Only a handful of exist- ing lines and those brought in from other states with private funds can be used. Although many researchers believe they hold the key to understanding and treating a wide assortment of human ail- ments — from some forms of cancer to advanced diabetes to ALS, or Lou Gehrig's Disease — it is illegal to create embryonic stem cell lines in Michigan. If Dr. Feldman and her staff did, they would be liable under Michigan law to $10 million in fines and 10 years in prison. So she had to set up a co-operative arrange- ment with the University of California at San Diego to conduct research that cannot be done in Ann Arbor. Michigan is one of six states that have enacted such laws. Voters will decide next month whether they want to uphold these restrictions or amend the state's constitution to permit expanded research. It will appear as Proposal 2 on the November ballot. A Tough Fight Taubman, whose institute funds much of this research, described himself as "exas- perated" by these impediments. "It is really a pathetic situation," he says, "and to make it worse, we are in danger of losing some of the best minds in the field. They want to go where they can carry on their research without having their hands tied. We are cutting off one of this state's U-M's Dr. Feldman: "We think now that stem cells can not only arrest nerve damage, but reverse it." most important assets. a Pandora's box of frightening research "Our opponents argue that using adult and weird science!' stem cells is just as effective, and they do Doyle insists it would lead to experi- have their place. But that place is limited ments in human cloning and that state and they can't be used over as wide a taxpayers would be on the hook for fund- range of research as embryonic stem cells!' ing the research. Many Jewish organizations, including Taubman calls these assertions "a total Hadassah and B'nai B'rith, are strongly lie.""They are telling us what research we in favor of Proposal 2. Several other indi- intend to do," he says, "and there is abso- viduals serve on the board of Michigan lutely nothing in that proposal that will Citizens for Stem Cell Research and Cures, cost Michigan taxpayers a dime." a nonprofit advocacy group, and other organizations backing the proposal. Positive Signs Opposing Proposal 2 is Michigan Even with the restrictions under which Citizens Against Unrestricted Science they work, Dr. Feldman's 35-person team and Experimentation, (Micause), which has come up with some encouraging includes the Michigan Catholic Conference results. In the battle against ALS, a disease and Right to Life of Michigan. Its spokes- that previously has resisted attempts to man, David Doyle, of the Lansing-based slow its progression or cure, they found Marketing Research Group, calls Proposal that spinal cord stem cells transplanted 2 "filled with false hopes and misinforma- into animals have the capacity to become tion in an attempt to hide from voters (its) new nerve cells and to attach themselves true intentions ... This proposal unleashes to sick cells and make them healthier. "The goal is to get approval for human trials;' says Dr. Feldman. "But the bulk of that work had to be done in California. It can't be done here. If I could do everything in Michigan, it would advance the pace of the work and make progress much more rapid." Israel has been among the world leaders in such research, with cutting edge work going on at the Technion-Israel Institute of Technology and Rambam Medical • Center in Haifa. Jewish religious leaders do not believe there is a halachic (Jewish law) prohibition on such research or that using a 5 -to 7-day-old embryo destroys human life. They regard its potential for healing and saving lives as a strong Jewish imperative. "Jewish tradition and religious law teach that saving lives is a paramount moral obligation," said Stephen B. Zorn, imme- diate past president of the Bloomfield Township-based Great Lakes Region B'nai B'rith International, in support of earlier bills in the Michigan Legislature that would have permitted embryonic stem cell research. "It is also an urgent issue for the Jewish community because it is one of the oldest demographic groups in the U.S. and par- ticularly hard hit by many conditions that could be addressed by this new research." B'nai B'rith is one of the sponsors of a documentary film on stem cell research by University of Michigan student Michael Rubyan. The West Bloomfield High gradu- ate, a pre-med student majoring in film, was drawn to the subject through the ill- ness of a relative. He hopes his film, which took 21/2 years to complete, "will help peo- ple connect with the issue by hearing from other people, and not just the experts." Several congregations in the area are helping to promote the film, which will be given its Detroit area premiere this Wednesday-Thursday, Oct. 15-16, at the Main and Maple theaters in Royal Oak and Bloomfield Township, respectively. (See adjacent story.) In addition, supporters of embryonic stem cell research are urging those who agree with them to send a letter backing Proposal 2 to any Michigan newspaper by visiting the Jewish Community Relations Council of Metropolitan Detroit homep- age, detroitjcrc.org, and clicking the link in the "What You Can Do" box. A Matter Of Life on page B10 October 9 • 2008 B9