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Dentistry this spring with a degree in
endodontics. She will sit for board
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Specialty Associates in Livonia.
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Community Health will receive the
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of Nursing and its board of visitors.
She has been a community health
educator at Providence Hospital and
Medical Centers for 10 years with a
special interest in women's services. •
Pola Friedman of Farmington Hills has
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at Hospice of Michigan. She is responsi-
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zation, which provides end-of-life care
to-more than 800 terminally ill people
daily throughout Michigan.
Dr. Michael D. Weiss of Troy was
recognized with the Distinguished
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College of Osteopathic Obstetricians .
and Gynecologists.
BRCA. Mutation
May be Helpful
International
Travel
Specialists
France & Israel July 12
Notes
e Ultimate Luxury Glatt
Kosher Cruise Experience
New York/JTA — There's finally good
health news for Jewish women of
Eastern and Central European
descent.
A genetic mutation that links some
Ashkenazi women to ovarian cancer
makes these women more responsive
to chemotherapy, according to a new
study.
Patients with what are known as
BRCA mutations who had advanced
ovarian cancer lived about two years
longer than patients in a similar stage
of cancer without the gene, according
to the study of 189 Jewish women.
The study was published in the
Journal of the American Medical
Association.
In addition, the time for recurrence
of the disease in patients with the
mutation was about 14 months, as
opposed to seven months for those
without the mutation.
Eighty-eight of the 1 89 women
studied had the mutation.
The finding "could open up new
possibilities of how to treat ovarian can-
cer," said Jeff Boyd of Memorial Sloan-
Kettering Cancer Center in New York,
which conducted the 12-year survey. He
added, however, that there are no
immediate practical applications.
"It's a paradox," said Boyd. "The
mutated gene is what leads to the can-
cer in the first place. But once it's
developed, it could be an Achilles'
heel for the tumor."
The genetic mutations that are
linked to breast and ovarian cancers
are more frequently found among
Jewish women of Ashkenazi descent
than among the general population.
A 1997 study into the risk of breast
and ovarian cancers among Ashkenazi
Jews found that a person with the
genetic mutations has a 56 percent
chance of getting breast cancer, and a
17 percent chance of getting ovarian
cancer by the age of 70.
Some 2 percent of Ashkenazi Jews
carry the BRCA1 or BRCA2 muta-
tions, according to the Human
Genome Project in Washington.
The incidence of cancer among
Ashkenazi Jews is not higher than
among those in the general popula-
tion, but more of their cancer risk
stems from genetic factors. -
Dr. Tammy Peretz, the head of the
Sharrett Institute of Oncology at
Hadassah Medical Center-Ein Kerem
in Jerusalem, welcomed the result.
The finding that cells with the
mutated BRCA genes become more
sensitive to therapy, suggested Peretz,
may also be applicable to those
women with one of the BRCA muta-
tions who develop breast cancer as
well.
A medical oncologist at the Mayo
Clinic in Rochester, Minn., was less
enthusiastic.
"It confirms what has been
observed clinically," Dr. Harry Long
said, adding that he would like to see
the study replicated because the group
with the mutations received a more
complete surgical removal of the
tumor before receiving chemotherapy.
A higher percentage of patients in the
non-BRCA group received an older
form of treatment.
Long also said he would like to see
the study performed on some of the
other BRCA mutations present in
non-Jewish women.
Despite his reservations, he said,
"For people who feel they've been
dealt a bad hand, it's an indication
that it's not as bad as previously
thought."