AUCTION AT THE

Weizmann Institute
Traces Alzheimer's

A "Science Forum" with Weizmann
Institute of Science Professor Joel
Sussman will be
held in
Bloomfield Hills
on Wednesday,
April 14.
Sussman, who
teaches in the
Department of
Structural
Biology,
authored a
Professor
Weizmann
Joel
Sussman
Institute study
-,that has implica-
tions for treating Alzheimer's disease.
The study shows exactly how a sub-
stance derived from Huperzine A, a
moss long used in Chinese folk
medicine, blocks the brain enzyme
acetycholinesterase (AchE), which
may be involved in Alzheimer's dis-
ease.
"It is as if this natural substance
were ingeniously designed to fit into
the exact spot, AchE, where it will
do the most good," noted Sussman,
who suggests that this may provide a
starting point for designing a new,
improved generation of drugs to
treat Alzheimer's disease.
According to one theory, memory
loss and other cognitive deficits in
-'=Alzheimer patients result from
degeneration of nerve cells that
release the message-carrying chemi-
cal acetycholine. The shortage of
this chemical is compounded by the
action of AchE, the enzyme that
brea'.,s down acetycholine in the •
1 body.
The new study — performed by
\- X-ray crystallography — revealed
exactly how the blocking of the
enzyme takes place. The U.S. Army,
the Weizmann Institute and the
Scientific Cooperative of the
European Union provided support
for the study.
In 1979, Sussman was awarded
the E.D. Bergmann Prize for out-
i\ standing research in chemistry in
Israel.
The Weizmann Institute of
Science, in Rehovot, Israel, is a cen-
ter of scientific research and gradu-
ate study for 2,500 scientists, stu-
dents, technicians and engineers.
The Science Forum will take
place at 7 p.m. in a private home.
For reservations, call Daphna Ruby
,-,it (248) 258-9890.

GALLERY

Friday, April 16th at 6:30 p.m.
Saturday, April 17th at 11:00 a.m.
Sunday, April 18th at Noon

Friday, April 9th
Saturday, April 10th
Monday, April 12th
Tuesday, April 13th
Wednesday, April 14th
Thursday, April 15th

FREE VALET PARKING ALL SALE DATES

Free Parking Wednesday Evening Exhibition

Exhibition Hours:

9:30
9:30
9:30
9:30

a.m. - 5:30 p.m.
a.m. - 5:30 p.m.
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Featuring the Estate of George and Lenna Blanche Carleton of
Grosse Pointe Farms, MI: the Estate of William canaver of Indian
Village; a collection of Victoriana from a suburb of Grand Rapids;
Native American pottery and Navajo rugs from a private collection
and antique silver and oil paintings from another.

William Shayer, (English 1788-1879), oil on canvas,
11" x 15". Sunday #2008

4. `

4t r

"*6)

-

Hughie Lee-Smith, (American 1916-1999), oil on board, 1954, 23" x 35",
"The Walls". Sunday #2009

Douglas Arthur Teed, (American 1864-1924). oil on
canvas, dated 1911, 23" x 30". Sunday #2006

•

GEORGE WASHINGTON ink signed
document, 1783, w. 5", 1. 11".
Sunday #2020

Pablo Picasso, (Spanish 1881-1873),
lithograph, 30" x 22" paper size
"Faune Musicien N". Sunday #2003

VICTORIAN AND EDWARDIAN HAT PINS,
late 19th c. to early 20th c., over 200,
h. 6" to 12". Friday #0180

#

Fine Arts Appraisers
,
and Auctioneers since 1927

Russian silver gilt, champleve
& precious jewel egg, h. 4".
Sun. #2011

Serapi semi-antique wool carpet, 9' x 12'. Sunday #2063

. Ogden Minton Pleissner, (American 1905-1983),
watercolor, sight 18" x 28". Sunday #2001

A 15% Buyer's Premium is added to each lot sold tip to anti including
1350.000 and 19% over $50,000 and is subject to 31ichigan Sales

Tax. Illustrated catalogs mailable at the Gallery for S20.(4), postpaid

$25.00 Express .flail and therseas S33.00. Annual subscriptions

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4/9
1999