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All Cosmetic and Reconstructive Surgery Non-Surgical Treatments • Surgery of the Face & Nose • Laser for Facial Wrinkles • Breast Surgery • Liposuction • Photoderm for Facial & Leg Veins •Tummy Tucks • Hair Transplants • Collagen Replacement Therapy • SoftForm Facial Implants Private Office Surgery Suites • Over 16 Years Experience 9/26 1997 200 Willaim J. Vasileff, m.d. • A. Kevin Muiderman, m.d. (248) 644-0670 • 525 Southfield Rd. • Birmingham Health Sometimes Disease And Defects Sow The Seeds Of Greatness CHERYL CLARK Special to The Jewish News ir incent van Gogh's "Starry Night" - painted in 1889, the year before his death - may not have been just the result of artistic genius. The green and yellow swirls in the sky probably stemmed from a long- term overdose of digitalis, prescribed for what was then believed to be epilepsy. The drug was extracted from the purple foxglove flower, seen in the Dutch painter's portrait of his physi- cian. Italian composer Niccolo Paganini's nimble fingers and joints enabled him to stretch his reach across three octaves on the violin. In fact, the musician owed his flexibility to Ehlers-Danlos syndrome, a congenital defect manifested by loose connective tissue in his fingers and wrists. Emperor Napoleon planned for months to take over Europe at the battle at Waterloo, but an agonizing bout with hemorrhoids on the morning of the attack kept Napoleon off his horse and delayed battle, giving the enemy time to fortify. Theories related to those and other famous people are part of the field of "pathogra- phy," the study and specula- tion of how disease, disfigure- ment or congenital defect influence accomplishment and set the stage for greatness. Or, in some cases, disaster. "It's a bit of detective work at great distance, especially when you put a couple of cen- turies in between," said Dr. Glenn Geelhoed, professor of surgery at George Washington University Medical Center in Washington, D.C. "It's just physicians' grown-up play," a hobby or chatty topic for the dinner party, said Dr. William Frosch, professor of psychiatry at Cornell University Medical College in Ithaca, N.Y. Pathography buffs ponder such unanswerable questions as whether the United States would have been formed if King George III had not suffered from the disease porphyria. Or more recently, whether former Zaire President Mobutu Sese Seko would have lost power to rebels if he Cheryl Clark writes for Copley News Service hadn't been weakened by prostate cancer. "People who stand out as being Ti \ / larger than life have distinguished themselves because of their personali- ty or traits that set them apart, and many times these are due to medical or genetic attributes," said Dr. Robert,-/ Marion, director of the Center for Congenital Disorders at Montefiore Medical Center in New York City, and author of a book on the subject. From history books and medical accounts, researchers glean the tiniest details of defects and deformities. "We ask how did they cope; how did they adapt to the deck they were given?" said Geelhoed. For example, -\ 'whether (physicist Stephen Hawking, confined to a wheelchair with Lou Gehrig's disease) could have written 'A Brief History of Time' if he had been able to play soccer?" Other examples include: • The Italian sculptor Cellini, who, after mercury cured his syphilis, created a sculpture in -c -/ tribute to the Roman god Mercury. • The composer Chopin, whose last works, including a funeral sonata, may have been influenced by recurrent respi- ratory infections and a chronic cough. At the time, Chopin was thought to have tubercu- losis; today, pathography experts speculate he had cystic fibrosis. • California Gov. Pete Wilson, whose throat surgeries kept him quiet during key months :f\ when his 1996 presidential campaign needed a forceful start. "We're all shaped by a combi- nation of genetics and environment," said Dr. Antonino Catanzaro, tuber- culosis expert at the University of California at San Diego School of Medicine. "We tend to think of dis- ease as a bad thing, but it isn't always. Some good things can come out of our responses to disease," he said. Catanzaro noted that early symp- toms of Alzheimer's disease may have actually helped the political career of former President Ronald Reagan, whose diagnosis was made public in 1994, five years after his presidency ended. "There's no question in my mind that it helped him be president," Catanzaro said. "His approach to pol- itics and the presidency was fascinat- DISEASE AND DEFECT on page 202