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CANCER GENE page 53
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185delAG mutation, all came
from Ashkenazic Jews.
Combining the results with
outcomes from testing pools of
other ethnic groups, researchers
concluded that 185delAG is three
times more prevalent in the
Ashkenazic segment of the Jew-
ish population than in the gen-
eral public.
But, researchers say the study
does not prove that women with
the mutation run an increased
risk of developing breast and
ovarian cancers. In other words,
having the mutation does not
necessarily guarantee a diagno-
sis.
"The problem with this data is
that we don't know enough yet,"
says Dr. William Peters, presi-
dent and chief executive officer
with the Barbara Anne Kar-
manos Cancer Institute in De-
troit.
The Karmanos Cancer Insti-
tute is one of 25 centers nation-
Drs. Carney & Lewis, P.C.
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Southfield, Michigan 48304
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wide designated by the NIH to
conduct cancer research, educa-
tion, community outreach and
treatment programs.
Dr. Linda Weiss, an assistant
professor at Wayne State Uni-
versity and an epidemiologist
with the Karmanos Cancer In-
stitute, says Jewish women
should not panic at the latest
news. In fact, researchers say it
is still too soon to recommend im-
mediate testing for the cancer
gene and the mutation.
Further studies of BRCA1 and
185delAG will take place in
Washington, D.C., and Long Is-
land, N.Y., during upcoming
months. NIH is cooperating with
Jewish communities in those ar-
eas to locate and screen Ashke-
nazim.
`There may in fact be many ge-
netic factors — and factors out-
side of genetics — that determine
breast-cancer risk," Dr. Weiss
says. "This may be just one of
them."
In Detroit, the Karmanos Can-
cer Institute invited doctors at
Sinai Hospital to a public forum
in Birmingham on Oct. 5. to dis-
cuss findings of the recent study.
Public-relations officials at the
Karmanos Cancer Institute say
they will alert Jewish communal