ro" AM. MAPLE Professor Sachs Elected To Post Weizmann Institute Professor Leo Sachs, the Otto Meyerhof Professor of Molecular Biology in the Department of Molecular Ge- netics and Virology, has been elected a Foreign Associate of the U.S. National Academy of Sci- ences. Professor Sachs has made pioneer contributions to eluci- dating the control of growth and differentiation in normal and cancer cells, including the dis- covery of the first cell culture sys- tem for cloning and clonal development of normal blood cells. Using this method he dis- covered the first protein regula- tors of this clonal growth and differentiation, which revolu- tionized molecular and cellular hematology. His discoveries have pioneered new approaches. The families of proteins that have been identified based on Professor Sachs' discovery in- clude those now called colony- stimulating factors and interleukins. His findings have led to the clinical use of these pro- teins to correct defects in blood cell development in patients with hematological disorders includ- ing cancer. He also showed that myeloid leukemic cells can be in- duced to differentiate to mature cells that are no longer malignant — by normal blood cell regulato- ry proteins or by other com- pounds that use alternative pathways of inducing differenti- ation. His findings have pio- neered new approaches and insights into the controls that regulate blood cell viability, growth and differentiation, the molecular basis of normal and abnormal development in blood- forming tissues, ways of sup- pressing malignancy in leukemic cells by inducing differentiation, and the use of blood cell regula- tory proteins to correct defects in blood cell development. In addition, Professor Sachs developed the first cell culture system for malignant cell trans- formation by chemical carcino- gens and radiation, which provided a new approach to studying carcinogenesis by envi- ronmental carcinogens and showed that by segregation of specific chromosomes, malig- nancy can be suppressed in sar- comas induced with different types of carcinogens. His studies on suppression of malignancy in sarcomas identified chromo- somes with genes for the expres- sion and suppression of malignancy. He also found that Finding us is as easy as We're here for you. And there for you. Everywhere in For after-hours questions, you can call our nursing your community. With 10 facilities near you, you're advice service and talk with an experienced nurse who never more than 15 minutes from Henry has immediate access to your medical information. 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