•-• ---

,..•

....„

'

L

•••: „,.

,..,

,

,,..

\NS,.

't -. .

-: k' .„
..\ ' k-

, 't,
,, -,. ,•-•

-,---•&. ',..- ''•••-,:-••••‘'
: , • :•,- '&4- -*••••

At Springhouse,
Mom gets the assistance
I wish I had time
to give her.

i

-

N • - • ,•::
...., • . ..
„ „.. ••••• ,

• - ••• =- - k -'' '.-:•‘ , k-• - •- •.

Blood Vessel Growth
Target Of Study

A

key

factor in the growth of
new blood vessels essen-
tial in the development of
both normal and malig-
nant tissues has been identified
in a Weizmann Institute study
published in a recent issue of Cell.
With regard to tumors, the for-
mation of new blood vessels al-
lows the malignant cells to
proliferate, enter the blood cir-
culation and travel to distant or-
gans. The Weizmann team has
found that a particular chain of
sugar molecules linked to a pro-
tein plays a central role in this
process. The scientists are now
attempting to design specific in-
hibitors of this chain that would
slow down blood-vessel formation
around the tumor, thereby re-
stricting its size and preventing
its metastatic growth.
The study was carried out by
Dr. Avner Yayon and doctoral
student David Aviezer of the In-
stitute's department of chemical
immunology, in collaboration
with Dr. Guido David of the Cen-
ter for Human Genetics in Leu-
ven, Belgium, and Dr. Magdalena
Eisinger of the American
Cyanamid Co. in Pearl River,
N.Y.
It has long been known that
blood-vessel formation, or angio-
genesis, is induced by a protein
known as fibroblast factor (FGF).
Four years ago Dr. Yayon found
that the FGF binds to cellular re-

At Springhouse we provide assisted
living services in a residential community
which protect the dignity and indepen-
dence of seniors. Our residents receive the
help they need with activities of daily
living, while maintaining as active and
independent a lifestyle as possible.
If you are concerned about the health and
security of your parent or other loved one,
and you want to help them preserve their
independence; visit Springhouse.We can
help improve their quality of life while
increasing your peace of mind.

For more information or a tour
please call us at (810) 358-0088
Or, clip out the coupon
and mail it to us.

Opening Soon In Southfield!

eYringhouse

ASSISTED ► LIVING

26111 Telegraph Road
Southfield, Michigan 48034

ceptors and induces cell prolifer-
ation only when it is attached to
specific protein-containing sugar
chains called proteoglycans. In
the current study the scientists
have identified a particular pro-
teoglycan, called perlecan, that
carries the chains most actively
involved in FGF binding. More-
over, perlecan was found to in-
duce FGF receptor activation and
angiogenesis even at extremely
low concentrations.

A particular chain of
sugar molecules
plays a central role.

These finding emerged from
experiments in which capsules
containing either perlecan by it-
self or a perlecan-FGF combina-
tion were introduced into animal
tissue. In both cases a solid, ex-
tensive network of blood vessels
developed.
This research was supported
in part by the Israeli Academy of
Sciences and the Humanities, the
Israel Cancer Research Fund, the
Minerva Foundation and the
United States-Israel Binational
Science Foundation. Dr. Yayon
is the incumbent of the Alvin and
Gertrude Levine Career Devel-
opment Chair of Cancer Re-
search. ❑

A Member of the Manor Care Family of Companies

JN

Please send me a full brochure.

NAME

ADDRESS

CITY

STATE

ZIP

PHONE

(

)

TRANSFER YOUR HOME MOVIES
8mm- 1 6mm TO VHS

COATS
UNLIMITED

CENTUR CiAktilEMI

Film Length In Feet
8mm & Super 8 & 16

1-200 Feet
201-400 Feet
401-600 Feet
601-800 Feet
801-1000 Feet

$20.00
$26.00
$39.00
$52.00
865.00

1 .‘..... Film Over 1,ON Feet Add 6 A Foot
(Video Tape $5.00 Additional)

58

3017 N. WOODWARD
t
v
ROYAL OAK CiZO

(3 Blocks South of 13 Mile)

r

Fall Special

Oak Park
'Lincoln Center 26150 Greenfield Road
Oak Park, MI 48237
(313)968-2060

1

West Bloomfield
Orchard Mall 6337 Orchard lake Road
West Bloomfield, MI 48322 (313) 855-9955

FREE
BACKGROUND
MUSIC

Troy
Troy Commons 871 E. Big Beaver Road
Troy, MI 48237
528.9966

On Any Video Transfer

Century Camera 288-5444

CLASSIFIED
GET RESULTS!

With This Coupon. Expires 2/27/95

810-288-544 1t

Daily & Saturday I 0-6
Friday I 0-8

I

Call The Jewish News

354-5959

Centers Of Excellence
Receive Study Grants

eizmann Institute re-
search into information
processing by the brain
and the properties of
electrons will be bolstered by two
research grants for centers of ex-
cellence, just awarded by the Is-
rael Science Foundation,
administered by the Israel Acad-
emy of Science and Humanities.
Centers of excellence at Israeli
institutions of higher learning —
five of which were created this
year — are established annually
on the basis of recommendations
by leading world experts in order
to promote scientific investiga-
tions at the highest possible lev-
el. Each center receives a
$900,000 research grant.
The Brain and Computation
project — conducted by four sub-
groups of scientists and coordi-
nated by Professor Shimon
Ullman of the Institute's depart-
ment of applied mathematics and

computer science — will focus on
clarifying how brain cells work
together to represent visual pat-
terns, such as simple shapes, in
the cortex. Another goal of the
project is to understand how dif-
ferent groups of brain cells inter-
act while performing perceptual
tasks, such as discriminating be-
tween various visual or tactile
patterns.
A unique feature of this re-
search is the close cooperation be-
tween neurobiologists on the one
hand, who will perform empiri-
cal observations of the brain, and
mathematicians and computer
scientists on the other hand, who
will develop computational mod-
els for interpreting these obser-
vations. Other unique aspects
include the focus on brain activ-
ity . at the level of cell networks
and the combination of different
techniques for recording such ac-
tivity.

N