Weizmann Study
Targets Treatment
0
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ctober is Breast Cancer
Awareness Month in the
United States and at the
same time, attempts to
tailor breast cancer treatment to
the tumor type may be bolstered
by a Weizmann Institute study
project that has just received the
support of the Susan G. Komen
Breast Cancer Foundation,
which provides more funds than
any other American private in-
stitution for research dedicated
solely to breast cancer.
The project is conducted by
physician and postdoctoral fel-
low Dr. Noa Ben-Baruch, who
works under the guidance of pro-
fessor YosefYarden of the Insti-
tute's Department of Chemical
Immunology, and is the first re-
searcher outside the United
States to receive a grant from the
Susan G. Komen Breast Cancer
Foundation. Dr. Ben-Baruch, an
oncologist specializing in breast
cancer, completed a three-year
fellowship at the national Can-
cer Institute in Bethesda, Md.
and in now dividing her time be-
tween patient care at the Sheibe
Institute of Oncology in Kaplan
Hospital and breast cancer re-
search at the Weizmann Insti-
tute.
She intends to correlate clini-
cal observations of breast cancer
patients with a laboratory analy-
sis of their tumors. Such corre-
lation may establish whether
Teitel Day-Care Unit
Dedicated In Israel
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certain molecular features of the
tumor cells — genes that may be
associated with the cancer, re-
ceptors for growth factors or var-
ious other elements — can help
predict the course of the disease.
Assessing the patient's prognosis
has important implications for
treatment — for example, it can
serve to identify women who
should receive anti-cancer drugs
after surgery.
A major part of Dr. Ben-
Baruch's project will be dedicat-
ed to studying the link between
various cellular pathways that
are crucial to breast cancer de-
velopment. In particular, she will
investigate Neu differentiation
factor (NDF), a substance first
identified by professor Yarden,
which activates specific onco-
genes that play a pivotal role in
the development of breast can-
cer. Dr. Ben-Baruch will also
study NDF's connection to the
chain of cellular events that fol-
lows the exposure of malignant
cells to the steroid hormones.
Loss of response to steroids is as-
sociated with more aggressive
behavior by breast cancer.
In the future, when the intri-
cacies of the steriod and oncogene
systems are fully understood, it
even may be possible to manip-
ulate them in an attempt to mod-
ify the clinical course of breast
cancer. ❑
H ARRaa1 T iktiv
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Participating in the dedication ceremonies were (left to right): Prof. Yehuda L.
Danon, CMCI director; Gerald S. Cook, a nephew of the Teitels and administrator of
the trust, and his wife, Barbara.
FABULOUS SHOPS IN ONE
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T
hrough the generosity of nounced this week by Professor
the estate of the late Ben Yehuda L. Danon, CMCI direc-
and Harriett Teitel of De- tor.
The Ben and Harriett Teitel
troit, a day hospitalization
center for child cancer patients Hematology-Oncology Day Care
has been established in their Center forms an integral part of
memories at the Children's Med- the 224-bed critical care hospi-
ical Center of Israel, it was an- tal's National Center for Hema-