A simple, non-toxic substance, derived from egg yolks and developed by the Weizmann Institute, offers the promise of inhibiting deadly virus' power to spread from one cell to another. Ti he stream of anguished letters, telegrams and telephone calls pours in every day from all over the world. Some days, there are as few as ten; other days, as many as 140. Each is a desperate cry for help from an AIDS victim in search of a miracle. Some do not bother to write or call. They simply take the first available flight to Israel and turn up at Kaplan Hospital or the Rokach-Hadassah Medical Center in Tel Aviv. "Some are terminal cases, most are in an advanced stage of the disease," says Dr. Yehuda Skorknick, of Rokach-Hadassah. "We have patients from almost every continent—from Europe, from the United States and Canada, from South Africa. And more are arriving every week." These life-seekers have heard from others, or via the gay press and AIDS in- formation networks, of a new, experimen- tal but highly promising AIDS treatment called AL-721, which was developed at the Weizmann Institute in Rehovot and which is now being tested at Kaplan Hospital and Rokach-Hadassah Medical Center. AL-721 is a buttery lipid compound derived from the humble egg yolk Patients spread it on toast or crackers or they can mix it into a juice ("It tastes pretty terri- ble," says one doctor, "but we can fix that"). Those receiving treatment do not even have to stay in the hospital—or, indeed, in Israel. They are simply sent home with a supply of AL-721 in 20-gram pots which they keep in the refrigerator and take daily. All the Israeli doctors ask is that pa- tients remain under close medical supervi- sion and send them regular clinical reports for evaluation. But the efficacy of this totally natural, non-toxic, seemingly simple nutrient is suf- ficiently dramatic to have generated a firestorm of hope among people who had lost all hope. Of the 60 AIDS victims who have been treated with AL-721 over the past year, 48 have shown a very considerable improve- ment in their general well-being, some- times within a few days of embarking on the treatment. They have lost much of the lassitude associated with AIDS, fevers have been reduced, other symptoms have diminished. And they have suffered no side effects. Three patients, who were considered ter- minal, are now in a state of remission. More importantly, clincial tests show that in the face of the treatment, the deadly virus loses much of its "infectivi- ty'—in other words, its power to spread from one cell to another. But AL-721 is not'and please, please be emphatic about this," says Dr. Skork- nick a cure for AIDS. "There is, as yet, no cure for AIDS and it would be wicked and irresponsible to claim otherwise." Dr. Skorknick and his colleagues, how- ever, readily concede that AL-721 may prove to be an important breakthrough in IT 1r ~ • •I /SI • 111■I •