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January 08, 1982 - Image 6

Resource type:
Text
Publication:
The Detroit Jewish News, 1982-01-08

Disclaimer: Computer generated plain text may have errors. Read more about this.

THE DETROIT JEWISH NEWS

6 Friday, January 8, 1982

The Saudis Disavow Favoring Recognition of Israel

Introducing

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(Continued from Page 1)
talk without preconditions
at any time and any place.
Israeli officials also re-
called that Riyadh engaged
in similar on again - off
again exercises in the last
few months. In mid-
November, Saudi Arabia's
acting delegate to the
United Nations, Gaafar Al-
lagany, said that Fand's
plan recognized Israel by af-
firming, in the seventh
point of the plan, "the right
of the countries of the region
to live in peace." Two days
later this view was officially
disavowed by "an official

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Saudi source."
Last May, Fand told the
Washington Post that if Is- ,
rael declared its willingness
to withdraw from occupied
territories, Saudi Arabia
would bring other Arabs to
negotiations. Four days
later he claimed that he had
been misquoted and a
month later called for a holy
war against Israel.
The Times report said
Prince Saud continued to
insist that American pol-
icy fostered Israeli in-
transigence. But at the
same time, he made it
clear "that his govern-
ment was not simply
going to wait for Wash-

JERUSALEM — A new
approach to combatting
malaria, which annually
claims two to three million
lives worldwide and affects
140 million people, has been
developed by scientists at
the Hebrew University of
Jerusalem.
The new idea is to kill the
malaria parasite present in
the body by poisoning it
with its own waste products.
Profs. Hagai Ginsburg
and Z. Ioav Cabantchik hit
upon the idea in the course
of their experiments on the
host-parasite relationship.
Malaria parasites,
when they invade red
blood cells, produce lac-
tic acid at 150 times the
rate of their host's red
blood cell. Normally, this
toxic acid is excreted
from the cell by means of
transport mechanisms in
the cell membrane.
Scientists know that
there are two mechanisms
which transport lactic acid
in the cell membrane, each
independent of the other. In
healthy blood cells, only one
of these systems is needed to
get rid of the lactic acid. In
malaria-infected cells,
when the rate of production
of lactic acid increases
greatly, the usual excretory

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system becomes saturated
and the second system is
pressed into service and
does the job.
But what happens when
the second excretory system
stops working? Profs.
Ginsburg and Cabantchik
found that the toxic lactic
acid which is not excreted
from the cell destroys the
invading malaria parasite.

So, if a way can be found
temporarily to stop the ac-
tion of the lactic acid excret-
ing mechanism, it should be
possible thereby to cure
malaria patients without
resorting to the traditional
anti-malarial treatments —
which are either toxic to the
patient (quinine) or are no
more effective due to drug
resistance developed by the
parasite. On this assump-
tion, Profs. Ginsburg and
Cabantchik have started
looking for ways to stop the
action of the excretory
mechanism.
They have continued
laboratory experiments
with drugs designed for
completely different
needs, but which are
known to block the lac-
tate excretory
mechanisms in red blood
cells. Among these are
Furosemide, a kidney
drug used for treating
edema, and Niflumic
Acid, an anti-
inflammatory drug. Both
drugs are inhibitory to
parasite growth in cul-
tures.
Now they are trying to
develop other drugs which
will affect the excretory
mechanism in the cell
membrane. If they succeed,
they may_ well come up with
a completely new drug for
malaria.
In the course of their re-
search, which is supported
by the World Health Organ-
ization, the World Bank, the
UN Development Program
and the Wolfson Research
Foundation, the scientists
also discovered that at a cer-
tain stage in its life cycle,
after it has invaded the red

plained that the islands
were part of Zone C, the de-
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peace treaty and therefore
Egypt was not free to dis-
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ington to change and that based on the Fand plan," the
equal effort was being Times reported.
devoted to end the con-
It noted that the inter-
flict among Arabs and view with Saud was con-
frame a united Arab ducted "in a period of un-
stand against Israel," the usual diplomatic activity by
Times reported.
Arab leaders that was
sparked in part by Israel's
It referred to the Arab annexation of the Golan
summit meeting in Fez, Heights."
Morocco last November
Israel
Meanwhile,
which broke up over the
Fand plan. "But Prince reacted to Prince Fand's re-
Saud said the plan was still cent assertion that Egypt
very much alive, that he should hand over the south-
hoped Arab leaders would ern Sinai islands of Snapir
reconvene 'in three or four and Tiran to Saudi Arabia
months' and that he 'hoped by warning that this would
and expected' that the next be a breach of Egypt's peace
meeting would result in 'a treaty with Israel.
common Arab position' The Foreign Ministry ex-

blood cell and before it Sub-
divides into additional
daughter-parasites, the
host cell membrane be-
comes highly permeable to
certain substances. Profs.
Ginsburg and Cabantchik
are now seeking materials
which will be able to cross
the permeable cell mem-
brane, attack the parasite
and destroy it, without
penetrating the body's other
tissue cells.

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